Neurology Alert
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Structural and Functional Imaging ‘Phenotypes’ in Refractory Temporal Lobe Epilepsy Patients
Using high-resolution 3-T magnetic resonance imaging, temporal lobe epilepsy-hippocampal sclerosis showed significant preoperative ipsilateral volume loss, T2 hyperintensity, and mean diffusivity increases across all subfields, with the greatest effects seen anteriorly. However, temporal lobe epilepsy-gliosis showed increased volume in the dentate gyrus bilaterally, and more focal and subtle increases in T2 intensity and mean diffusivity.
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What is the End Game in Creutzfeldt-Jakob Disease Progression?
Cerebellar and psychiatric symptoms at diagnosis of Creutzfeldt-Jakob disease may portend a higher risk for more rapid development of akinetic mutism.
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For Migraine Pain, Green Light May Give Relief
Migraine-related photophobia appears to originate in cone-driven retinal pathways and is then mediated by thalamic neurons. Green light causes less stimulation than other colors.
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Guillain-Barré Syndrome in the Elderly
Guillain-Barré syndrome in the very old (> 80 years of age) results in more severe disease with poorer recovery.
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Cerebral Microbleeds Are Risk Factor for Symptomatic Intracerebral Hemorrhage in Patients Undergoing IV Thrombolysis
Cerebral microbleeds, as visualized on gradient-echo or susceptibility-weighted MRI, are considered markers of bleeding-prone cerebral microvessels and constitute a significant and independent predictor of future intracerebral hemorrhage.
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Which Patients with TIA Are at High Risk for a Recurrent Cerebral Vascular Events?
Recurrent cerebral vascular events are one of the main determinants of outcome in patients after minor strokes and transient ischemic attacks.
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Dual Antiplatelet Therapy Appears More Effective Than Single Therapy
How long should duel antiplatelet therapy after stroke or transient ischemic attack last?
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Epidemiology of Neuromyelitis Optica Spectrum Disorders in Two Distinct Populations: Black and White
Based on an epidemiological study in two ethnically and geographically distinct populations of patients diagnosed with central nervous system inflammatory demyelinating diseases, the authors report a higher prevalence among Afro-Caribbean patients in Martinique in the eastern Caribbean sea vs. a predominantly Caucasian population in Olmstead County in Minnesota. The study demonstrates a propensity for neuromyelitis optica to affect blacks more than Caucasians.
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Blood-Based Biomarkers in the Evaluation of Alzheimer’s Disease
At the present time, no blood-based biomarkers have been identified as reliable indicators of A-beta amyloid deposition in the brain.
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Greater Weight Loss Later in Life Is Associated with Increased Risk of Mild Cognitive Impairment
In a population-based, prospective study of subjects 70 years of age or older, increasing weight loss per decade from midlife to late-life was associated with an increased risk of incident mild cognitive impairment.