Neurology Alert
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Autoimmune Antibodies in Patients with Epilepsy of Unknown Etiology
In this prospective study of patients with epilepsy of unknown origin (including new-onset and established epilepsy), more than 20% of patients were found to have neurological autoantibodies strongly suggesting autoimmune origin of their epilepsy.
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A Novel Target for Migraine Prevention Through Modulation of Stress Receptors
Kappa opioid receptors (KORs) modulate response to stress, a common migraine trigger, so KOR blockade may be a novel preventive treatment for migraine as well as other stress-related diseases.
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Outcomes After Surgical Treatment of Nonlesional Neocortical Epilepsy
In this study of 109 consecutive patients with medically refractory neocortical epilepsy without MRI-identifiable lesions who underwent focal resection at a single hospital from 1995 to 2005, almost 60% of patients achieved long-term seizure freedom, with anti-epileptic drugs being withdrawn successfully in about a third of these patients.
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Bright-light Therapy for Daytime Sleepiness in Parkinson’s Disease Patients
Light therapy has been shown to be beneficial in treating excessive daytime sleepiness in Parkinson’s disease patients and also may improve sleep quality.
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Fludrocortisone for Orthostatic Hypotension Associated With Parkinson’s Disease
This double-center, double-blind, randomized, controlled trial compared the efficacy of pyridostigmine bromide vs. fludrocortisone and demonstrated that pyridostigmine bromide was not as effective as fludrocortisone. The authors also provided evidence for the efficacy of fludrocortisone in treating neurogenic orthostatic hypotension.
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Rituximab for Myasthenia Gravis
In uncontrolled, observational case series, rituximab treatment for myasthenia gravis appears to be effective and safe, but more studies are needed for confirmation.
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Blood-brain Barrier Breakdown in RCVS
In this single-center, prospective trial, patients with reversible cerebral vasoconstriction were found to have evidence of blood-brain barrier breakdown on MRI.
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Stroke Rehabilitation
These articles are based on the editor's personal interactions as a participant at the International Stroke Conference in Houston, Feb. 22-24, 2017. All interpretations and opinions are exclusively those of the editor.
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Aneurysms and AVMs
These articles are based on the editor's personal interactions as a participant at the International Stroke Conference in Houston, Feb. 22-24, 2017. All interpretations and opinions are exclusively those of the editor.
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In-hospital Management of Stroke
These articles are based on the editor's personal interactions as a participant at the International Stroke Conference in Houston, Feb. 22-24, 2017. All interpretations and opinions are exclusively those of the editor.