Neurology Alert
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Mild Traumatic Brain Injury Induces Altered Sleep and Impaired Memory
Traumatic brain injury may induce a chronic state of altered sleep with impaired memory consolidation and mood disorders.
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Treatment of Intracerebral Hemorrhage Guided by the ‘Spot Sign’
Although the “spot sign” is a predictor of early hematoma expansion, selective treatment of this group with aggressive antihypertensive therapy did not alter hematoma size or neurological outcome.
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Direct DNA Sequencing of Dominant Cerebellar Ataxias
Current genetic testing techniques with DNA sequencing can diagnose the molecular-genetic causes for the majority of dominantly inherited cerebellar ataxias.
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Severe Olfactory Impairment Is Associated With Preclinical Alzheimer’s Disease
In this cross-sectional, population-based, cohort study of 829 cognitively normal participants, abnormal neuroimaging biomarkers known to be associated with Alzheimer’s disease were associated with severe olfactory impairment.
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Plasma α-Synuclein Is a Leading Candidate Biomarker in Parkinson’s Disease
In this cross-sectional study, plasma alpha-synuclein levels were higher in individuals with Parkinson’s disease than controls, and correlated with cognitive decline.
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Tacrolimus for Treatment of Myasthenia Gravis
A large observational study performed in Korea suggests that tacrolimus is an effective immunomodulating, steroid-sparing medication for the treatment of myasthenia gravis.
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Prediction of Survival After Cardiac Arrest Using Pupillometry
Automated infrared pupillometry holds promise as a quantitative, reproducible measure that aids in determining neurological prognosis after cardiac arrest and coma.
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Atypical Transient Symptoms Require Aggressive Investigation for Cause
Atypical transient symptoms, such as partial sensory deficit, dysarthria, vertigo and unsteadiness, unusual visual deficits, and diplopia, usually are not classified as transient ischemic attacks, and they frequently are not investigated in the same fashion. However, one-year risk of recurrent major vascular events was not significantly different between patients who had typical TIA symptoms or atypical isolated or non-isolated symptoms. Therefore, these patients should be investigated intensively in a manner similar to patients with classical TIA symptoms.
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What Is the Risk of Hemorrhage During Pregnancy for a Woman with Brain Arteriovenous Malformation?
The risk of hemorrhage in a pregnant woman with a brain arteriovenous malformation (AVM) is uncertain and management is controversial.
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Deep Brain Stimulation May Offer Hope in Treating Post-stroke Pain
This trial of deep brain stimulation of the ventral striatum/anterior limb of the internal capsule improved several measures of the affective sphere of pain in those suffering from post-stroke pain, despite no significant improvement seen in the pain disability index.