Neurology Alert
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Migraine With Aura, Stroke Risk, and Biomarkers
A longitudinal cohort study of twins found no increased stroke risk related to migraine overall, but there was a modestly increased risk for stroke related to migraine with aura. Familial factors and vascular biomarkers associated with migraine with aura may explain its correlation with vascular disease.
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Diabetes, HbA1c, and Neuropathy
The hallmark of neuropathy associated with type 2 diabetes is reduction of sensory nerve action potential amplitude and not a reduction in conduction velocity, supporting the hypothesis that hyperglycemia causes axonal dysfunction and injury.
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Noninvasive Vagus Nerve Stimulation for Indomethacin-Sensitive Headaches
Trigeminal autonomic cephalgias are notoriously difficult to treat and may be responsive to noninvasive vagus nerve stimulation.
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Childhood Head Trauma and Risk of Subsequent Diagnosis of Multiple Sclerosis
A large study that reviewed longitudinally collected data from the national Swedish Patient Register found that head trauma in adolescents was associated with an increased risk of subsequent diagnosis of multiple sclerosis.
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Exploring Cortical Pathology in Multiple Sclerosis With Routine MRI
In this MRI and histopathological study, the investigators showed that cortical T1w/T2w ratio was unrelated to myelin density, but had a strong correlation with dendritic density. Furthermore, abnormal values within the posterior cingulate cortex correlated with impairment in cognitive domains.
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Pitfalls in the Treatment of Seizures Associated With Brain Tumors
In this multicenter, observational study, the authors assessed the prevalence of neuropsychiatric side effects from medications in subjects with tumor-related epilepsy. Levetiracetam was found to have the highest prevalence of such side effects.
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What Is the Ideal Target for Blood Pressure Control?
Patient-reported outcomes in a recent trial of subjects who received intensive treatment with a target systolic blood pressure of < 120 mmHg were similar to those who received standard care, supporting the recommendations of SPRINT.
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Cerebrolysin Is Unproven as a Neuroprotectant for Acute Ischemic Stroke
The routine use of Cerebrolysin in acute stroke is not justified.
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Idarucizumab for Reversal of the Anticoagulant Effects of Dabigatran
The administration of idarucizumab is effective and safe for the reversal of the direct thrombin inhibitor, dabigatran, and should be used in appropriate clinical situations.
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Sudden Prehospital Death From Subarachnoid Hemorrhage
Based on recent nationwide data reported from Finland, one-fourth of those experiencing their first ever subarachnoid hemorrhage died suddenly before being admitted to a hospital.