Neurology Alert
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Correlation of Electromyography With Pathology in Myopathy
A detailed analysis of electromyography features showed a high correlation with muscle pathology. However, pathologic changes on muscle biopsy may be present even with a totally normal electromyogram.
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Apolipoprotein E and CSF Levels in Men and Women With Alzheimer’s Disease
Apolipoprotein E epsilon 4 (APOE4) genotype, the stronger genetic risk factor for late-onset Alzheimer’s disease, negatively affects cerebrospinal levels of tau protein in a sex-dependent manner, whereby the effect of APOE4 is stronger in women than men.
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Utility of Ictal Magnetoencephalography for Identifying Seizure Onset Zone
In a review of 377 magnetoencephalography (MEG) studies in epilepsy patients undergoing presurgical workup, 44 patients were found to have one or more seizures during routine recordings, lasting up to a mean of 51.2 minutes. Ictal MEG provided unique localizing data in about one-third of patients. For patients with frequent seizures or reliably induced seizures, MEG may be a useful supplemental tool for medically refractory epilepsy patients undergoing presurgical evaluation.
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Effect of Sleep on Levodopa-Induced Dyskinesia in Parkinson’s Disease
Parkinson’s disease is associated with sleep disorders commonly. Disrupted sleep patterns appear to make dyskinesias worse in patients treated with levodopa therapy.
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Oral Anticoagulant-associated ICH
Intracerebral hemorrhage is the most dangerous and feared complication of oral anticoagulation and leads to a high mortality. Debate continues about the relative risk of hemorrhage with two classes of oral anticoagulants.
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A Biomarker to Help With Neurologic Prognosis After Cardiac Arrest
Determining the prognosis of neurological outcome after cardiac arrest is notoriously difficult. Neurofilament light chain is a new potential biomarker, for which elevated levels in the spinal fluid or blood indicate axonal injury in several neurological diseases.
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Are Women More Prone to Brain Injury Than Men When Playing Soccer?
Repeated subconcussive injuries to the brain, such as “heading” the ball in soccer, result in more severe injury and slower recovery in women compared to men.
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Idiopathic Adult-onset Laryngeal Dystonia
Researchers demonstrated that isolated laryngeal dystonia in an Italian population can spread to contiguous regions, thus expanding knowledge of dystonia spread and phenomenology of this rare form of dystonia.
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Zika-associated vs. Non-Zika Guillain-Barré Syndrome
Guillain-Barré syndrome associated with Zika virus is similar to non-Zika virus cases in terms of severity of illness and prognosis around long-term recovery and disability.
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Comparison of Two Apheresis Techniques for Treating Relapses in Neuromyelitis Optica Spectrum Disorders
Based on a large study of patients in a national registry, investigators reported similar efficacy when comparing the two apheresis techniques: plasma exchange vs. immunoadsorption for the treatment of relapses in NMOSD. Early initiation of apheresis was associated with better outcomes.