Neurology Alert
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Is it Chronic Inflammatory Demyelinating Polyneuropathy or Charcot-Marie-Tooth Disease?
Charcot-Marie-Tooth disease may be confused with chronic inflammatory demyelinating polyneuropathy, resulting in inappropriate and hazardous treatments. Age at onset < 40 years, a family history of neuropathy, absence of nerve hypertrophy on magnetic resonance imaging, and poor response to intravenous immune globulin treatment should prompt a genetic evaluation.
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Functional Cognitive Disorder: An Important Condition for Neurologists to Recognize
Functional cognitive disorder (FCD) is a term that can be used to describe cognitive difficulties that are present where there is no biologic cause, but a lack of consensus in diagnostic criteria limits its use in clinical practice and research. Ball and colleagues proposed an operational definition for FCD as the cognitive phenotype of functional neurological disorder.
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Mortality and Costs of Status Epilepticus
In an analysis of a large group of patients hospitalized with status epilepticus, based on an administrative database, patients who required a third line of intravenous anesthetic agents had the highest mortality and highest hospital costs.
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Occipital Nerve Stimulation in Medically Intractable Chronic Cluster Headache
Occipital nerve stimulation is an effective and safe treatment that can help reduce attack frequency and intensity in patients with medically intractable chronic cluster headache.
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Dietary Modifications with Linoleic Acid Can Have an Effect on Gut and Brain Inflammation
This study evaluated the use of dietary conjugated linoleic acid (CLA) supplementation to modulate the disease outcome in a spontaneous mouse model of central nervous system autoimmunity and also studied patients with relapsing-remitting multiple sclerosis receiving CLA supplementation. CLA may act as a modulator of the gut-brain axis by targeting immune cells in the gut, with a subsequent effect in the brain.
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Neuromuscular Complications of Graft-Versus-Host Disease
Graft-versus-host disease is common in allogeneic bone marrow recipients, but neuromuscular complications are unusual (8%). The most common neuromuscular complication is an immune-mediated myositis that responds to treatment with immunosuppressive therapies.
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CSF Biomarkers May Distinguish MSA from Lewy-Body Alpha-Synucleinopathies Before the Onset of Debilitating Symptoms
In patients with autonomic failure, the combination of elevated neurofilament light and alpha-synuclein oligomers in the cerebrospinal fluid can distinguish between multiple system atrophy and Parkinson’s disease/dementia with Lewy bodies. Early diagnosis is critical for the development of treatment trials.
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Recovery of Consciousness After TBI: Who Recovers and When?
The majority of patients with moderate to severe traumatic brain injury who survive and are treated in acute rehabilitation centers will recover consciousness.
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Back Pain-Related Disability and Lumbar Spine Imaging Changes
A population-based, prospective cohort study of women in the United Kingdom found no association between the number of lumbar segments with radiographic pathology and severity of back pain-related disability.
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Prophylaxis for Tuberculosis in Patients with Myasthenia Gravis
In this observational study from an area with a high rate of endemic tuberculosis (TB), prophylactic treatment of TB was appropriate in those treated with high doses of prednisone and evidence of prior TB infection.