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Low intensity warfarin therapy effectively prevents recurrent venous thromboembolism, according to a recent study in the New England Journal of Medicine.
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On February 26th, the FDA approved a transdermal formulation of oxybutynin for the treatment of overactive bladder and urinary incontinence. Oxytrol Patch (Watson Pharmaceuticals) provides 3.9 mg/d and can be administered twice per week.
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This population report investigated the prevalence of gluten sensitivity amongst a large cohort of patients with both sporadic and familial ataxia.
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Almost all patients with diabetes eventually develop neuropathy. New therapeutic options for the control of painful diabetic neuropathy are constantly being investigated.
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Mutations in a-synuclein and parkin have been described in families with Parkinsons disease, and both gene products are involved in the function of the proteosome, a major pathway for degradation of proteins within the cell.
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HMG-CoA reductase inhibitors (statins) are known to reduce the risk of myocardial infarction and stroke. Statins are effective not only as cholesterol lowering agents but also have beneficial effects on endothelial cell function, as well as antithrombotic and anti-inflammatory effects.
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Vigabatrin (VGB) is an antiepileptic drug (AED) whose putative mechanism of action is to increase inhibitory tone in the brain by blocking the metabolism of gamma-amino butyric acid (GABA) by irreversibly binding to GABA transaminase.
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Benign hyperckemia may be defined as serum elevation of creatine kinase (CK) in an asymptomatic patient or in a patient with nonspecific symptoms, including muscle pain, fatigue, cramps, stiffness, normal neurological examination, and normal or nondiagnostic electrodiagnostic (nerve conduction studies and electromyography) studies.
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Taylor and associates report a case of Hashimoto encephalopathy in an adolescent girl with a 9-month history of what was initially diagnosed as chronic fatigue syndrome.
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Several previous studies have reported inverse associations between fish intake and the risk of stroke in men and women. A randomized trial in patients with coronary heart disease, however, found that supplementation with fish oil reduced the risk of acute myocardial infarction but not of stroke.