Multiple Sclerosis
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Stroke Alert
Carotid MRI scanning was performed in 1414 stroke-free participants, older than the age of 45 years, to assess the morphology of any atherosclerotic plaques, specifically to look at the presence of a lipid core, intraplaque hemorrhage, calcification, or fibrous tissue in each carotid artery. -
DaTSCAN to Distinguish Parkinson’s Disease from Secondary Parkinsonism
DaTSCAN imaging makes use of the dopamine transporter (DAT) ligand [123I]FP-CIT used with SPECT to provide a means to visualize the integrity of the nigrostriatal dopaminergic system. DaTSCAN has been approved in the United States to aid in evaluation of patients in whom Parkinsons disease (PD) and certain other related neurodegenerative disorders are suspected. -
Utility of Anti-JC Virus Antibody Index to Assess the Risk of PML in Natalizumab-Treated MS Patients
Natalizumab is a monoclonal antibody that is FDA-approved for the treatment of relapsing-remitting multiple sclerosis (MS). Among the available options to treat MS, it is one of the most effective. -
Intravenous Calcitonin Gene-Related Antibodies for the Prevention of Migraine
In a Phase 2 trial, antibodies to calcitonin gene-related peptide resulted in a significant decrease in migraine days measured from baseline to weeks 5 to 8 after one intravenous infusion of the medication, as compared to a placebo infusion. But the high-rate of placebo response (50%) warrants caution in the interpretation of the study results and requires more investigation. -
Cumulative Index: Volume 20, Numbers 1-12, Pages 1-96, September 2001 — August 2002
An index of Neurology Alert articles organized by topic. -
Increased Caloric Intake Increases the Risk of Alzheimer’s Disease
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Neuropsychological Assessment Reduces False Positives in Mild Cognitive Impairment
Synopsis: Traditional comprehensive neuropsychological testing has greater reliability, sensitivity, and specificity than bedside screening tests in the accurate diagnosis of mild cognitive impairment. -
Role of Neurologists and Diagnostic Tests in the Management of DSP
Synopsis: Using the clinical history and simple, inexpensive laboratory tests, community-based outpatient neurologists were able to determine the cause of distal symmetric polyneuropathy in three-fourths of patients presenting with typical symptoms. -
Chemotherapy-Induced Neuropathy in Pediatrics
Synopsis: Chemotherapy-induced peripheral neuropathy is common in children treated for a variety of cancers, but the long-term prognosis for recovery is excellent. -
To Sleep, Perchance to Clear Our Beta-Amyloid
SYNOPSIS: Both animal studies and human data suggest that A-beta 42 amyloid is cleared from the brain during sleep, and that sleep deprivation may be a risk factor for the development of Alzheimer’s disease.