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Statins and liver function; dosing timing for thyroxine; rivaroxaban for VTE, DVT, and stroke; echinacea and the common cold; and FDA actions.
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With the development of an increased understanding of cellular biology, in general, and the regulation of eosinophils, in particular, the heterogeneous diagnosis of hypereosinophilic Syndrome (HES) has now been better defined and a classification system has been developed with clear clinical implications.
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Very limited data are available on autologous transplant outcomes for uncommon or rare multiple myeloma (MM) subtypes.
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The occurrence of skin rash in patients receiving cetuximab is common, and for patients with colon cancer, this has been associated with better clinical outcomes.
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A 74-year retired veterinarian presents to the emergency department (ED) with shortness of breath. He was recently diagnosed with diffuse large-cell lymphoma with prominent abdominal lymphadenopathy and positive bone marrow and has been treated with two cycles of R-CHOP.
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The U.S. Food and Drug Administration (FDA) has recently approved denosumab for the prevention of skeletal-related events in patients with bone metastases from solid tumors.
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Rivaroxaban may be dabigatran's first competitor; a new way to measure non-adherence to medication therapy; FDA Actions.
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A trial undertaken by EORTC was designed to determine if neoadjuvant chemotherapy would be successful in the absence of post-surgical chemotherapy in enhancing overall survival in patients with locally advanced gastric cancer. The trial did not accrue sufficient numbers of patients to demonstrate a survival benefit. However, presurgical chemotherapy was associated with a higher rate of complete resection and fewer positive lymph nodes, features that suggest progression-free and overall survival might be favorably affected.
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In a retrospective review of consecutive patients with colon cancer, the presence of diabetes mellitus was found to confer negative prognostic information with regard to overall, and cancer-specific, survival. Notably, it was in patients with stage II disease that the presence of diabetes was of most importance.
