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There has been much written about the salutary effects of moderate alcohol consumption in reference to a number of non-malignant chronic diseases. The effects on cancer in general are less compelling. However, in the current meta-analysis examining alcohol consumption and the development of renal cell carcinoma, a protective effect for light and moderate drinkers is clearly demonstrated. This protective effect is in the 10-20% range.
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Self-reported personal history of endometriosis was associated with an increased risk of ovarian cancer. Further, it was differentially associated with clear cell, endometrioid, and low-grade serous ovarian carcinoma in this pooled analysis. No relationship appeared between endometriosis and high-grade serous or mucinous ovarian cancer, or borderline variants of these two histologies. The results suggest further work is necessary to understand whether endometriosis plays a strategic precursor role in certain ovarian cancer histological subtypes.
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In a retrospective review of 267 patients evaluated at M.D. Anderson Cancer Center with apparent early-stage, node-negative breast cancer, 15% were found to harbor "occult" metastases upon more intensive scrutiny of the axillary node specimens. In this series, long-term follow-up indicates that such discovery was not associated with a greater frequency of recurrence or poorer survival.
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In a small, single-institutional, prospective, randomized, placebo-controlled trial, 14 eligible patients (median age 47 years) with clinical and radiographic evidence of radiation necrosis secondary to prior head-and-neck or CNS irradiation were randomized to receive intravenous saline of bevacizumab at 3-week intervals. Patients were followed with serial MRI scans, neurologic examinations, and formal neuropsychological examinations.
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Aspirin and cancer prevention; rivaroxaban for pulmonary embolism; new rhinosinusitis practice guidelines; and FDA actions.
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A 61-year-old small business owner was seen in consultation for advice regarding management of a newly discovered pulmonary mass. Seven years previously, he had a 3.5 cm moderately differentiated adenocarcinoma of the sigmoid colon resected along with four regional nodes, all of which were negative for metastatic involvement.
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This randomized Phase 3 clinical trial found that adding cetuximab to standard mFOLFOX6 adjuvant chemotherapy did not improve either overall survival or disease-free survival in patients with resected stage III colon cancer, including those with wild-type KRAS tumors.
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In a meta-analysis of current observational (both case-control and prospective cohort) studies evaluating the potential association between type 2 diabetes mellitus and the incidence of hematological malignancy, an increased risk for non-Hodgkin lymphoma and leukemia was demonstrated as well as a trend toward an increased risk for myeloma. Confounding factors such as age, obesity, smoking, and alcohol (risks for both diabetes and malignancy) could not be completely accounted for in such an analysis.