Lipids
RSSArticles
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The Effect of Age on Cholesterol-Lowering Therapy
Investigators analyzed data on the effect of age on cardiovascular (CV) outcomes and LDL cholesterol-lowering by alirocumab vs. placebo in recent acute coronary syndrome patients. They found alirocumab can lower the rate of CV events regardless of age — and produce more absolute benefit with age.
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A New Treatment for Refractory Hyperlipidemia
In patients with familial hypercholesterolemia who are not at target LDL cholesterol levels on maximum-tolerated doses of statins and PCSK9 inhibitors, evinacumab, which inhibits angiopoietin-like 3, reduces LDL by more than 50% at the highest doses with few side effects requiring drug discontinuation vs. placebo.
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The Effect of Age on Cholesterol-Lowering Therapy
Investigators analyzed data on the effect of age on cardiovascular (CV) outcomes and LDL cholesterol-lowering by alirocumab vs. placebo in recent acute coronary syndrome patients. They found alirocumab can lower the rate of CV events regardless of age — and produce increasing absolute benefit with age.
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Scientists Observe Possible Relationship Between Autism Subtype, Cholesterol Levels
Results of this investigation confirm the challenges of understanding autism, its subtypes, and the arcane causes.
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Delays in Transfer For Primary PCI in STEMI
Most patients with ST-elevation myocardial infarction (STEMI) present to hospitals that are not capable of percutaneous coronary intervention (PCI). Rapid transfer to PCI-capable facilities for primary PCI may result in earlier reperfusion of the infarct artery and better clinical outcomes. However, delays in transfer may diminish the mortality benefit achieved with primary PCI in STEMI. -
Assessment of Functional Severity of Coronary Lesions by CT Angiography — FFRCT
Anatomic definition of coronary artery lesions by invasive coronary angiography (ICA) or computed tomography coronary angiography (CCTA) has limitations. -
BNP in Chronic Aortic Regurgitation
The most appropriate time to intervene in asymptomatic patients with chronic severe aortic regurgitation is controversial. Since brain natriuretic peptide (BNP) is released by the heart in response to increased wall stress, it has been proposed as a biomarker of the time to intervene in chronic valvular regurgitation patients. -
Laser Pacemaker Lead Extraction in Octogenarians
In this paper, Rodriguez and his colleagues from the Department of Cardiothoracic Surgery at the University of Miami report their experience with laser-assisted cardiac rhythm device lead extraction in a large group of patients. -
Pharmacology Watch
New recommendations for HPV vaccine; guidelines for treatment of essential tremor; updates on smoking cessation drugs; and FDA actions. -
Clinical Briefs in Primary Care Supplement