Internal Medicine
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Is Metformin a Wonder Drug?
An analysis of patients taking metformin for diabetes showed they were less likely to report back, knee, neck/shoulder, or multisite musculoskeletal pain.
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Another Agent for Hypercholesterolemia
A pooled analysis of three randomized, controlled trials of inclisiran in patients with atherosclerotic cardiovascular disease or its risk equivalent showed impressive reductions in LDL cholesterol with subcutaneous injections every six months.
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Importance of Atherosclerotic Disease Risk Factors in Myocardial Infarction Patients
ST-elevation myocardial infarction patients without standard risk factors recorded a higher all-cause mortality rate that was particularly evident in women. Using proper therapy in these patients may attenuate this risk.
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Efficacy of the Ross Procedure in Young Adults with Aortic Valve Disease
Young patients who underwent the Ross procedure recorded high rates of survival and low rates of reintervention long term.
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ECG Abnormalities in Elite Male and Female Athletes
A study of elite international soccer athletes of both sexes revealed women more often recorded what would be considered abnormal ECGs — only to return normal echocardiograms. This knowledge is especially valuable when treating those who have recovered from COVID-19.
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New Treatment for Postural Orthostatic Tachycardia Syndrome
A study of ivabradine in patients with the common hyperadrenergic subtype of the postural orthostatic tachycardia syndrome led to slower standing heart rates, lower plasma norepinephrine levels, and improved quality of life after one month.
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What About These T Waves?
The ECG in the figure was obtained from a middle-aged man with new-onset chest pain. How would one interpret this tracing?
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Bamlanivimab and Etesevimab Injection
Bamlanivimab and etesevimab should be prescribed to treat mild-to-moderate COVID-19 in adults and pediatric patients (age 12 years and older, weight at least 40 kg) who test positive for COVID-19 and are at high risk for progressing to severe disease and/or hospitalization.
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Compression Garments Effective in Reducing Cellulitis
Researchers examined the benefit of compression garments in patients with lower extremity edema at risk for cellulitis. Eligible patients reported significant edema for more than three months in one or both legs, and a history of two or more episodes of cellulitis in the same leg within the previous two years.
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Low BNP Levels in Up to 16% of Heart Failure Patients
In patients with clinical heart failure and low B-type natriuretic peptide levels, the authors found these patients usually are young and obese, with higher ejection fraction and better renal function.