Internal Medicine
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Neuromuscular Complications of Graft-Versus-Host Disease
Graft-versus-host disease is common in allogeneic bone marrow recipients, but neuromuscular complications are unusual (8%). The most common neuromuscular complication is an immune-mediated myositis that responds to treatment with immunosuppressive therapies.
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CSF Biomarkers May Distinguish MSA from Lewy-Body Alpha-Synucleinopathies Before the Onset of Debilitating Symptoms
In patients with autonomic failure, the combination of elevated neurofilament light and alpha-synuclein oligomers in the cerebrospinal fluid can distinguish between multiple system atrophy and Parkinson’s disease/dementia with Lewy bodies. Early diagnosis is critical for the development of treatment trials.
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Recovery of Consciousness After TBI: Who Recovers and When?
The majority of patients with moderate to severe traumatic brain injury who survive and are treated in acute rehabilitation centers will recover consciousness.
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Back Pain-Related Disability and Lumbar Spine Imaging Changes
A population-based, prospective cohort study of women in the United Kingdom found no association between the number of lumbar segments with radiographic pathology and severity of back pain-related disability.
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Chamomile and Diabetes
A systematic review of recent studies of the effects of chamomile on metabolic profiles suggests a positive effect on glycemic control, lipid profiles, and diabetic complications. -
Dietary Influences on Rheumatoid Disease
An extensive systematic review of research exploring the relationship between diet and the risk of rheumatoid arthritis as well as disease activity concludes that some dietary patterns and supplements may be protective enough to be recommended as part of the holistic management of rheumatoid disease -
A Null Finding: Vitamin D3 Supplementation Not Associated with Depression Prevention
This randomized clinical trial involving more than 18,000 nondepressed adults at baseline and followed for five years concludes that supplementation with vitamin D3 (vs. placebo) is not associated with a decrease in symptoms of depression. -
Determining the ‘Culprit’ Artery
How would one interpret the ECG in the figure, obtained in the ED from a middle-aged man with new chest pain? -
Aducanumab-avwa Injection (Aduhelm)
The FDA has approved a new, but controversial, treatment for Alzheimer’s disease. -
Using Procalcitonin to Limit Antibiotic Treatment for Sepsis Reduces Infection-Related Adverse Events
By shortening the duration of antibiotic therapy, a procalcitonin-guided protocol decreased the rate of infection-associated adverse effects, decreased costs, and reduced mortality in patients with sepsis.