Internal Medicine
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Vitamin and Mineral Supplements for Cardiovascular Disease
A meta-analysis of systematic reviews and randomized controlled trials to analyze the role of commonly used dietary supplements for prevention and treatment of cardiovascular disease suggests no significant effect on cardiovascular outcomes or all-cause mortality, although some B vitamins appear to reduce stroke incidence, and B3 appears to increase all-cause mortality.
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Is it Chronic Inflammatory Demyelinating Polyneuropathy or Charcot-Marie-Tooth Disease?
Charcot-Marie-Tooth disease may be confused with chronic inflammatory demyelinating polyneuropathy, resulting in inappropriate and hazardous treatments. Age at onset < 40 years, a family history of neuropathy, absence of nerve hypertrophy on magnetic resonance imaging, and poor response to intravenous immune globulin treatment should prompt a genetic evaluation.
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Functional Cognitive Disorder: An Important Condition for Neurologists to Recognize
Functional cognitive disorder (FCD) is a term that can be used to describe cognitive difficulties that are present where there is no biologic cause, but a lack of consensus in diagnostic criteria limits its use in clinical practice and research. Ball and colleagues proposed an operational definition for FCD as the cognitive phenotype of functional neurological disorder.
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Mortality and Costs of Status Epilepticus
In an analysis of a large group of patients hospitalized with status epilepticus, based on an administrative database, patients who required a third line of intravenous anesthetic agents had the highest mortality and highest hospital costs.
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Occipital Nerve Stimulation in Medically Intractable Chronic Cluster Headache
Occipital nerve stimulation is an effective and safe treatment that can help reduce attack frequency and intensity in patients with medically intractable chronic cluster headache.
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Diabetes Self-Management Education and Support Delivered Through Digital Health
The digital world offers a wide array of health tools to improve the participation of patients with diabetes in diabetes self-management education and support (DSMES). DSMES provides knowledge, proficiency, and resources to assist people with diabetes in integrating newfound skills and understanding toward effective management of this complex condition psychologically, biologically, and physically. -
Infectious Disease Alert Updates
Sepsis Bundle Erodes Gains in Stewardship; Asymptomatic Transmission of COVID-19 in Households; When Is Hand Hygiene Personally Protective? -
Quinacrine for Refractory Giardiasis
Quinacrine is highly effective in the treatment of giardiasis that is recalcitrant to initial therapy with other agents, but patients must be warned about neuropsychiatric effects. -
The Use of Proton-Pump Inhibitors and the Risk of Acquiring Community-Associated Clostridioides difficile Infection
A nationwide cohort study of adults in Denmark found that proton-pump inhibitor (PPI) use was associated with a moderately increased risk of community-associated Clostridioides difficile infection, and the risk remained elevated up to one year after PPI treatment had stopped. -
Amebic Meningoencephalitis
Primary amebic meningoencephalitis is a rarely diagnosed worldwide disease associated with exposure to fresh water that causes highly lethal, rapidly progressive central nervous system infection but may be treatable in some cases, necessitating maintenance of a high index of suspicion in appropriate cases.