Internal Medicine
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FDA Gives Full Approval to Pfizer’s COVID-19 Vaccine
A significant milestone in the ongoing battle against the pandemic.
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Treatment of Seizures After Spontaneous Intracerebral Hemorrhage
The reported incidence of post-stroke seizures varies and appears to have a higher incidence following hemorrhagic stroke. Post-stroke seizures have been associated with a greater length of hospitalization, increased mortality, and complications. This study compared four seizure prophylaxis strategies to determine the greatest net benefit for patients with spontaneous intracerebral hemorrhage. There was a better outcome with short-term antiepileptic medication use compared to long-term use.
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Cortical Lesions Correlate with Disability in Patients with Multiple Sclerosis
In a long-term, 30-year follow-up study of a cohort of patients with multiple sclerosis who presented with clinically isolated syndrome, the investigators found that, among the variables assessed, the presence of cortical lesions had the highest association with long-term physical and cognitive disability.
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Proteomics: A New Method to Understand the Influence of Genetic Variation on Disease Pathogenesis
The combination of genome-wide association studies with the analysis of messenger ribonucleic acid and unique proteins in the brain, cerebrospinal fluid, and plasma can shed new light on our understanding of the genetic risks for the development of various neurological diseases.
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What Is Focal CIDP?
Chronic inflammatory demyelinating polyneuropathy (CIDP) usually is diagnosed in patients who have a generalized disorder. However, there are focal syndromes that have been observed and diagnosed under different names that meet many of the clinical and electrodiagnostic criteria of CIDP and may be referred to as “focal” CIDP.
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MRI Changes and Functional Outcomes Among Adults with Severe HSV Encephalitis
Herpes simplex virus is a common cause of encephalitis worldwide. When treated promptly, the mortality rate decreases from 70% to 15%, but many patients remain disabled. This multicenter cohort study analyzed magnetic resonance imaging in patients diagnosed with herpes simplex encephalitis admitted to the intensive care unit to identify factors associated with poor outcome at 90 days.
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Infectious Disease Alert Updates
California mandates COVID-19 vaccine for healthcare workers; Seasonal coronavirus in stem cell transplant
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Adherence to the Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) Does Not Lead to Improved Clinical Outcomes
A longitudinal study from a single healthcare system found that adherence to the Medicare Severe Sepsis and Septic Shock Early Management Bundle resulted in some changes in process measures, but did not lead to improvements in clinical outcomes.
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Treatment of Presumed Urinary Tract Infection in Afebrile Males: How Long Is Long Enough?
Symptom resolution after seven days of antibiotic therapy in afebrile males with presumed urinary tract infection was not inferior to 14 days of therapy.
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COVID-19: Effective Post-Exposure Prophylaxis
Subcutaneous administration of a combination of anti-SARS-COV-2 antibodies effectively prevented COVID-19 in most household contacts of cases.