Internal Medicine
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A Simple Way to Measure Frailty Before Aortic Valve Replacement
An analysis of transcatheter vs. surgical aortic valve implantation showed modified BMI, a measure of frailty, predicted one-year all-cause mortality and postoperative complications.
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Mammograms as a Cardiometabolic Disease Prevention Tool
In a study of women undergoing routine mammographic screening for breast cancer, mammographic features, such as microcalcifications and breast density, were associated with the risk of developing cardiovascular disease.
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Using Cardiac MRI to Detect Suspected Tumors
Among patients with suspected cardiac tumors, cardiac MRI was highly accurate at distinguishing tumor from thrombus and benign from malignant tumors, using subsequent clinical data over five years of follow-up as the diagnostic standard.
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The Limits of Shortened Antiplatelet Therapy in Acute Coronary Syndrome
One month of dual antiplatelet therapy (DAPT) followed by clopidogrel monotherapy did not meet criteria for noninferiority vs.12 months of DAPT for a composite endpoint of ischemic and bleeding events.
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Benefits of Early Coronary Angiography in Acute Heart Failure
For patients hospitalized with acute heart failure, invasive coronary angiography within 14 days was associated with higher rates of coronary revascularization and lower rates of all-cause death, cardiovascular mortality, and heart failure hospitalization.
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In Addition to the Rhythm
The ECG in the figure was obtained from a middle-aged woman who presented with a febrile illness and shortness of breath. She reported no chest pain. In addition to the rhythm, what else is going on?
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Dihydroergotamine Nasal Spray (Trudhesa)
DHE nasal spray can be prescribed to treat migraine in adults with or without aura.
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Iron Therapy for Acute Heart Failure
Giving intravenous ferric carboxymaltose to stabilized post-acute heart failure patients with iron deficiency improved quality of life vs. placebo-treated patients within four weeks, which persisted during subsequent therapy for up to 24 weeks.
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Proton-Pump Inhibitors and Community-Associated Clostridioides difficile Infection
A nationwide cohort study of adults in Denmark found that proton-pump inhibitor (PPI) use was associated with a moderately increased risk of community-associated Clostridioides difficile infection, and the risk remained elevated up to one year after PPI treatment had ended.
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Clostridioides difficile Infection: Guideline Update
Fidaxomicin is preferred over vancomycin for initial and recurrent cases. Bezlotoxumab is recommended in many cases of recurrent infection and initial infection in patients at high risk of recurrence.