Internal Medicine
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Long-Term Post-TAVR Survival and Permanent Pacemaker Implantation
An analysis of a real-world database revealed 14% of patients undergoing routine transfemoral transcatheter aortic valve replacement required permanent pacemaker implantation within 30 days of the valve procedure. There was no difference in long-term survival between patients who did and did not undergo pacemaker implant.
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Importance of Age in the Application of Coronary Artery Calcium Detection
Using coronary CT strategy as a diagnostic first line in patients with symptoms suggestive of coronary artery obstruction revealed relying on the coronary calcium score alone is inadequate for younger patients with a higher frequency of non-calcified obstructions.
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Coronary CT Angiography in the General Population
Coronary artery CT angiography in asymptomatic, middle-aged subjects without known coronary artery disease showed coronary atherosclerosis is common but mostly mild and appears in women after a 10-year delay.
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Intensive Monitoring for Asymptomatic Atrial Fibrillation Did Not Prevent Strokes
Screening with an implantable loop recorder resulted in dramatically higher rates of atrial fibrillation detection and ensuing anticoagulation, but without a significant decrease in risk of stroke or systemic embolism by six years of follow-up.
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Cost to Treat U.S. Patients with Rare Diseases Likely Underestimated
NIH, FDA, other groups form consortium to speed gene therapy development.
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Antibiotics for Appendicitis, Revisited
One year later, researchers present updated data that strengthen the alternative to surgery approach.
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Regulators Sign Off on COVID-19 Vaccine ‘Mix and Match’
Federal agencies expand, clarify guidance on booster shots.
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What Is the ‘Bix Rule?’
The ECG in the figure was obtained from a middle-aged man with a history of exertional chest pain and dyspnea. How would one interpret this tracing? Does the red arrow in lead II show a sinus P wave?
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Atogepant Tablets (Qulipta)
Atogepant can be prescribed to prevent episodic migraine in adults.
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Progression of Coronary Calcium on Statin Treatment
In those treated with statins vs. those who were not, statins decreased plaque volume in plaques with little or no calcium (plaque regression) and increased calcium density without changes in plaque volume in calcified plaques (plaque stabilization).