Internal Medicine
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Jugular Venous Pressure by Bedside Ultrasound
Using a handheld point-of-care ultrasound device to estimate right atrial pressure from images of the jugular vein resulted in a higher imaging success rate vs. visual inspection and a reasonably accurate estimation, especially in those with elevated right atrial pressures.
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Importance of Exercise Testing-Associated Ventricular Ectopy
A study of asymptomatic subjects without known cardiovascular disease undergoing treadmill exercise testing and followed for a mean of 20 years showed high-grade premature ventricular contractions during exercise recovery (but not during exercise) are predictive of subsequent cardiovascular mortality.
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Post-TAVR Patients with Atrial Fibrillation Bleed Less on Vitamin K Antagonists vs. Edoxaban
In this randomized trial of post-transcatheter aortic valve replacement patients with atrial fibrillation, edoxaban was noninferior to vitamin K antagonists with regard to a composite of adverse endpoints, but was associated with a higher rate of major bleeding.
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New Treatment for Hypertrophic Obstructive Cardiomyopathy
A study of the echocardiographic characteristics of symptomatic patients with obstructive hypertrophic cardiomyopathy treated with mavacamten showed a persistent 30-week improvement in several key pathophysiologic characteristics.
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List of Possible Cancer-Causing Agents Grows Longer
Six water disinfection byproducts, plus a flame retardant and a bacterial infection, now considered potential human carcinogens.
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National Alzheimer’s Plan Updated with New Focus on Healthy Aging
Feds add sixth goal in the ninth version of this annually released report.
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Post-Exercise Premature Ventricular Contraction, or Aberrancy?
The ECG in the figure is a post-exercise tracing. There are four wider and slightly early occurring beats in the long lead rhythm strips. Are these beats premature ventricular contractions or premature atrial contractions conducted with aberration?
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Nirmatrelvir and Ritonavir Tablets (Paxlovid)
The FDA has issued an emergency use authorization for the first oral regimen for the treatment of COVID-19.
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Incidence, Prevalence, and Long-Term Consequences of Small Fiber Neuropathy
Small fiber neuropathy (SFN) associated with diabetes and other causes is more likely to progress to large-fiber polyneuropathy, deteriorate faster, and cause worse disability vs. slow progression with idiopathic SFN.
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Coronary CT Angiography in the General Population
Coronary artery CT angiography in asymptomatic, middle-aged subjects without known coronary artery disease showed coronary atherosclerosis is common but mostly mild and appears in women after a 10-year delay.