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Golimumab is indicated for the treatment of adults with moderately to severely active rheumatoid arthritis in combination with methotrexate (MTX), active psoriatic arthritis, and active ankylosing spondylitis with or without methotrexate or other non-biologic disease-modifying antirheumatic drug (DMARD).
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Insomnia persists.
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Despite a clear-cut association between asthma and gastroesophageal reflux, aggressive PPI treatment had no clinical effect on poorly controlled asthma.
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Patients with chronic heart failure (CHF) report progressively worse dyspnea with exercise, ranging from Class I NYHA (symptoms only present with strenuous exercise) to Class IV NYHA (symptoms present with any activity, even at rest).
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Brown adipose tissue is involved in temperature regulation, and relates to metabolic rate and body mass index. Its activity appears to be reduced in people who are obese.
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A survey of U.S. primary care physicians found that although most recommend weight loss to their obese patients, they do not utilize current evidence-based recommendations, and they underestimate the therapeutic effects of small weight losses.
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This report describes the unfortunate case of a woman who unwittingly exposed herself to moderately high-dose zinc supplementation for a period of years without attendant copper supplementation, ultimately suffering irreversible neurologic consequences due to copper deficiency.
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Results of this large, retrospective cohort investigation suggest that cumulative significant childhood stress and trauma contribute to development of systemic inflammation and autoimmune disease during adulthood.