Internal Medicine
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Was the 1889-1891 Russian Flu Really Coronavirus?
The 1889-1891 Russian flu pandemic was noted to spread rapidly through Western Europe, Great Britain, and North America. Contemporary clinical reports described prominent gastrointestinal, rheumatologic, and neurologic abnormalities (including loss of taste and smell), and pathologic reports described prominent thrombosis. A molecular clock analysis suggests a beta coronavirus emerged in humans following cross-species transmission around this time.
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Is a Cure for HIV Possible Without Stem Cell Transplantation?
In a 30-year-old woman with HIV not on antiretroviral therapy (the “Esperanza patient”), an analysis of 1.188 billion peripheral blood mononuclear cells and 503 million mononuclear cells from placental tissue revealed no genome-intact or replication-competent HIV-1 proviruses. This indicates a sterilizing cure of HIV-1 infection.
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Initial Antibiotic Choice for Neonatal Sepsis in Low- and Middle-Income Countries
Gram-negative rods are responsible for most neonatal sepsis in low- and middle-income countries. Ampicillin-gentamicin usually has been recommended for presumptive treatment, pending bacteriology results (when such tests are available). The results of a multinational study in Africa and Asia suggest resistance to standard therapy is widespread and that ceftazidime-amikacin might be a better option.
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AMA Asks to Remove Prescription Status from Naloxone
The request was made in the wake of a study that revealed expanded access to the opioid reversal agent is needed in almost every U.S. state.
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Third Documented HIV Remission Case Emerges
Woman with acute myeloid leukemia underwent stem cell transplant, which apparently sent the virus into remission.
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Survey Shows How Leaders Can Improve Obstetric Emergency Training, Education
Opportunities exist to enhance knowledge on health conditions that affect pregnant and postpartum patients.
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CGRP Antagonists: What Is Their Role in Headache Therapy?
Migraine is a highly prevalent and debilitating condition that causes significant impairment in quality of life. Preventive therapy for migraine is indicated when migraine attacks interfere with quality of life or are frequent and debilitating. The ability to prevent migraine with pharmacologic therapy has long been a goal of both patients and their physicians. The ideal preventive (prophylactic) migraine treatment should be effective, safe, and well tolerated, with few or no contraindications, few or no drug interactions, safety in pregnancy and breastfeeding, and dosed in a manner to ease adherence.
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Patient Pool Eligible for Lung Cancer Screening Expands Under Amended Criteria
CMS lowers age, smoking history thresholds.
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More Research Needed on How Marijuana Affects Human Brain
American Heart Association conducts thorough literature review on the subject.
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Midline Catheters May Be a Safer Option than Peripherally Inserted Central Catheters
Whenever possible, use of midline catheters over peripherally inserted central catheters could be safer for patients.