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In the early 2000s, substantial evidenced-based interventions were added to the care of critically ill patients that significantly reduced mortalityincluding low tidal volume ventilatory support for acute respiratory distress syndrome (ARDS), protocolized sedation with daily awakening, Drotrecogin-alpha for severe sepsis, tight glycemic control, corticosteroids for refractory septic shock and preventative strategies for ventilator associated pneumonia.
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In this prospective observational study, Kollef and associates enrolled patients with ventilator-associated pneumonia (VAP) in 20 ICUs across the United States in order to characterize the patients and the antimicrobial regimens used in treating them, as well as their mortality and lengths of stay.
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In this randomized-controlled trial, Koeman and associates wanted to determine the effect of two oral decontaminating gels, chlorhexidine 2% (CHX) or chlorhexidine 2% plus colistin 2% (CHX/COL), compared to a placebo, on the development of ventilator-associated pneumonia (VAP) in patients requiring more than 48 hours of mechanical ventilation.
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Febuxostat Compared with Allopurinol in Patients with Hyperuricemia and Gout; Prognostic Value of Serial B-Type Natriuretic Peptide Testing During Follow-up of Patients with Unstable Coronary Artery Disease; Dietary Fiber Intake and Risk of Colorectal Cancer
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Acid suppression, particularly with proton pump inhibitors (PPIs) is correlated with an increased risk of community-acquired Clostridium difficile colitis.
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Metabolic syndrome is common and is associated with an increased risk for CVD and T2DM in both sexes.
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Tretinoin solution helps heal diabetic foot ulcers.
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The FDA has approved a cfc-free levalbuterol aerosol inhaler for the treatment of asthma. Levalbuterol is the active isomer of albuterol and has been available in a nebulized solution for many years. This new formulation is marketed by Sepracor as Xopenex HFA.