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In 2001, the PROWESS trial of 1690 patients with severe sepsis1 demonstrated that a 96-hour infusion of activated protein C, or drotrecogin alfa (activated) (DrotAA, Xigris®) at 24 g/kg/h decreased mortality at 28 days from 30.8% to 24.4% (P = 0.005).
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It has been said that "medicine is a science, patient care is an art and healthcare is a business." To that end, physicians wear three hats, and must possess a broad range of skills to perform their jobs effectively. This demand is acutely evident in the tasks of an intensive care unit (ICU) director.
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Studies using computed tomography have shown that patients with the acute respiratory distress syndrome (ARDS) typically have a cephalocaudal gradient in the distribution of lung density, with the greatest density (and collapse) in the lung bases adjacent to the diaphragm.
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Over a 3-month period, all patients who required mechanical ventilation in the ICU of Tygerberg Academic Hospital in Cape Town, South Africa, were enrolled in this study.
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Associations between the number of patients managed (hospital volume) and improved patient survival have been extensively documented in the surgical literaturesuch as cardiac surgery, ruptured aortic aneurysm, and several types of cancer surgeryand suggested for selected medical conditions, such as acute myocardial infarction and the acquired immunodeficiency syndrome.
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New Hope for Macular Degeneration?; Can Cialis be Used for Edema?; FDA Actions
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Each year in the United States, a few isolated cases of plague are reported. This year, possibly because of increased spring rains leading to an increase in the rodent population, an unprecedented 13 cases of plagues have occurred in 4 states (New Mexico, California, Colorado, and Texas).
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A prospective study of the immunogenicity and reactogenicity of one vs 2 doses of 2004-2005 trivalent influenza vaccine (TIV), in 5 8-year-old children, was conducted among 280 children who had not received TIV. Of these, 222 received 2 doses of TIV and had 3 blood samples. An additional 10 received 2 doses of TIV and were included in the safety analyses. The mean age of the 222 children was 6.5 years; 57% were male.