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In a population-based study using hospital discharge diagnosis codes, patients with sleep apnea who underwent knee arthroplasty or open abdominal procedures were more likely to require invasive mechanical ventilation and to be diagnosed with aspiration pneumonia or ARDS than were matched patients without sleep apnea. Knee-replacement patients, but not those undergoing laparotomy, also were more likely to be diagnosed with pulmonary embolism.
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A third dipetdyl peptidase-4 (dpp-4) inhibitor has been approved by the FDA. Linagliptin follows sitagliptin and saxagliptin to the market. It is marketed by Boehringer Ingelheim as Tradjenta.
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Important differences in adherence to antihypertensive drug therapy occurred depending on the drug class prescribed with the lowest adherence noted to occur with diuretics and beta-blocker therapy and the highest adherence was observed with ARB or ACI therapy.
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In this issue: ACEI/ARB therapy for AS; safety alert issued for dronedarone; statins and cancer risk; nesiritide and heart failure; and FDA actions.
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The association of HPV infection and bladder cancer has been a topic of discussion for the last decade, but has not surfaced because of important other outcomes of HPV infection. HPV is increasing in its prevalence globally and its chronic nature raises many issues in and around the genital tract.
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Herrera and colleagues reviewed the use of interferon-ã release assays (IGRAs) for the diagnosis of latent tuberculosis infection (LTBI).
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A total of 1,763 HIV-1 serodiscordant couples in nine countries with the infected partner having CD4+ counts of 350-500/mL were randomized 1:1 to early (immediate) vs. delayed (CD4+ had declined to ¡Ü 250/mL or after development of an AIDS-related illness) antiretroviral therapy of the infected partner.