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Tadalafil, Eli Lillyâs blockbuster drug for erectile dysfunction, has now been approved to treat signs and symptoms of benign prostatic hyperplasia. Tadalafil is the first drug of its class to be approved for this indication.
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In a randomized, double-blind, placebo-controlled trial, clonidine and venlafaxine both proved superior to placebo in reducing hot flashes in breast cancer patients. The study was insufficiently powered to prove superiority of one drug over the other. However, venlafaxine produced earlier reductions and it appeared clonidine had more sustained effect (i.e., at 12 weeks of treatment).
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The authors conclude that patients with coronary stents undergoing an invasive procedure are at high risk of perioperative cardiovascular and bleeding complications, and that these are associated with a high mortality.
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Recent retrospective studies in Europe have created concern because of an observed increased risk of cancer (hazard ratio = 1.55) in users of insulin glargine (GLAR) compared to nonusers.
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A newly developed instrument to measure brief physical activity counseling in primary care demonstrates that physicians need to do a better job.
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From a large cohort of women followed prospectively and with an adjunct meta-analysis of existing evaluable studies, a clearly demonstrated, nearly universal (i.e., across tumor types) incremental increase in cancer incidence was observed with advancing height.
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Admission to an ICU increased risk for unintentional medication discontinuation in four of five medication groups commonly used to manage a chronic illness.
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Patients who have had percutaneous coronary intervention (PCI) with either bare metal stents (BMS) or drug-eluting stents (DES) require dual antiplatelet therapy until the stent struts are endothelialized. However, patients who have had prior PCI often need to undergo surgery.
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In this study from a single medical ICU, prompting physicians to discuss all six items on a daily rounding checklist, as compared with the use of the same checklist without prompting, significantly improved several processes of care and appeared to decrease length of stay and mortality as well.