Internal Medicine
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Update in Treating Neuropathic Pain
In an exhaustive review of the literature with a meta-analysis, the following medications were found to be most efficacious in the treatment of neuropathic pain: gabapentin, pregabalin, serotonin-noradrenaline reuptake inhibitors including duloxetine or venlafaxine, and tricyclic antidepressants.
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Is it Time to Give Up on Systemic Cooling in ST Segment Elevation MI?
Systemic hypothermia as a means to protect against tissue damage is a strategy that has found its way into clinical practice guidelines in the post-cardiac arrest population, in which cooling has demonstrated a neuroprotective effect in multiple contemporary clinical trials.
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Angiotensin Receptor Blockade, Renal Function, and Outcomes in Chronic Heart Failure
Renin-angiotensin-aldosterone (RAAS) blockade is an important component of guideline-recommended therapy for heart failure with reduced ejection fraction (HFrEF).
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‘The Butterfly Effect’ Explains Weather Triggering of Migraine
For about 13% of patients with migraine, a change in weather may be a trigger for some headaches; however, there is no specific perturbation in meteorological measures that is likely to predict a headache.
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Autologous Hematopoietic Stem Cell Transplant for Relapsing-Remitting MS
Interim analysis at 3 years post-treatment of a study of high-dose immunosuppression and autologous hematopoietic stem cell transplant for relapsing remitting-multiple sclerosis demonstrates sustained disease control but also shows potential risks associated with this treatment.
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Is Pediatric-onset Multiple Sclerosis a Neurodegenerative Disorder?
ABSTRACT & COMMENTARY: Pediatric-onset multiple sclerosis compromises age-expected brain growth.
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Reservoir Bugs: CRE in Long-term Acute Care Hospitals Threatens to Spread to Other Facilities
With a combination of severely ill patients, high antibiotic use, and lengths of stay measured in weeks, long-term acute care (LTAC) hospitals have been described as a perfect storm for emergence of multidrug-resistant organisms (MDROs).
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Infectious Disease Alert Updates
Water Birth Death
Out, Damned Spore!
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Preventing Active Tuberculosis in Children
A three-month course of weekly rifapentine and isoniazid is safe and at least as effective as nine months of daily isoniazid in preventing tuberculosis in children aged 2 to 17 years.
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Steroids for Severe Community-Acquired Pneumonia: More Evidence or More Uncertainty?
A multicenter, randomized, double-blind, placebo-controlled trial involving patients with severe community-acquired pneumonia and evidence of high inflammation found less treatment failure in those who received steroids. However, in-hospital mortality did not differ between the groups.