Internal Medicine
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See No Lights, Hear No Alarms: Sleeping in the ICU
ABSTRACT & COMMENTARY: Sleep quality in the ICU can improve. Here's how.
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Folate Supplements and Primary Stroke Prevention
The study has significant implications for stroke prevention across the globe by utilizing a safe and inexpensive folate supplementation or fortification strategy.
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Long-Term Weight Loss Rivals Medications and Ablation for AF Rhythm Control
Weight loss alone compares quite favorably with other strategies for AF rhythm control.
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New Insight into Anthracycline Cardiotoxicity
Cardiotoxicity occurs early on, and with prompt initiation of standard medical therapy for systolic heart failure, most patients can usually recover LV function.
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Antiplatelet Therapy After TAVR: Where are the Data?
Dual antiplatelet therapy is associated with higher rates of bleeding compared with aspirin alone, but evidence supporting its efficacy post-transcatheter aortic valve replacement is sparse.
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Is It Time to Purge Full-Strength Aspirin from the Outpatient Armamentarium?
There's further evidence of a lack of benefit to high-dose maintenance aspirin, along with a suggestion of harm.
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Risk of NSAID use in patients receiving antithrombotic therapy after myocardial infarction
Among patients receiving antithrombotic therapy after MI, the use of NSAIDs was associated with increased risk of bleeding and excess thrombotic events, even after short-term treatment.
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Early, goal-directed therapy of septic shock
One thousand two hundred sixty patients with early septic shock were randomized to early, goal-directed therapy vs. usual care. Hemodynamic management according to a strict protocol did not lead to an improvement in outcome.
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Hospital wards with higher rates of antibiotic prescribing associated with increased risk for C. diff infection
A retrospective observational study found that among hospitalized patients, ward-level antibiotic prescribing was associated with a significantly increased risk for C. difficile infection beyond what would be expected with patient-level antibiotic use.
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Vasospastic angina with myocardial infarction – more dangerous than once thought?
Patients with vasospastic angina and a type II myocardial infarction have a worse prognosis than previous believed.