Internal Medicine
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Diagnosing POLG-related Diseases
Mutations of the polymerase-gamma subunit in mitochondrial DNA is a common cause of adult mitochondrial syndromes, such as myopathies, encephalopathies, epilepsy, and ataxias.
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Prevalence of Rest Tremor in Essential Tremor
Rest tremor is seen in patients with more advanced essential tremor, yet its prevalence varies significantly between patient groups.
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Cerebrospinal Fluid Biomarkers of Neuronal Injury in Mild AD
Cerebrospinal fluid visinin-like protein 1 is a useful marker, along with CSF tau and phospho-tau measurements, to predict brain atrophy and neurodegeneration in patients who carry a clinical diagnosis of Alzheimer’s disease.
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Serum and CSF Biomarkers of Brain Injury After Sports-related Concussion
ABSTRACT & COMMENTARY: So far none of the currently measured biomarkers has sufficient sensitivity or specificity to be clinically useful.
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Obstructive Sleep Apnea
MONOGRAPH: Continuous positive airway pressure devices remain the mainstay of treatment. If CPAP is poorly tolerated, here are your options.
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Prevention of Proton Pump Inhibitor-induced Bowel Symptoms with Probiotics
The administration of a Lactobacillus paracasei strain (F19) twice daily and 3 times per week for 6 months appears to reduce the incidence of bowel symptoms (bloating and flatulence) and reduce changes in bowel habits (increased stool frequency and loose stools) but not abdominal pain in patients taking proton pump inhibitors.
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Sustainable 25(OH)D Levels? Choose Vitamin D3 over D2
Compared to vitamin D2, daily supplementation with vitamin D3 appears to sustain serum 25(OH)D levels even after discontinuation of supplementation in healthy adults.
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Spiritual Interventions for Patients with Cancer
A systematic meta-analysis investigating the effects of spiritual intervention in patients with cancer found that spiritual interventions had significant moderate effects on spiritual well-being, meaning of life, and depression.
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Integrative Therapies for Fibromyalgia – What News?
Although fibromyalgia remains a challenging management problem in clinical medicine, significant progress has been made in the last five years in terms of identifying underlying neurobiological abnormalities, which may one day elucidate the pathophysiology of the disorder.
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Infectious Disease Alert Updates
Point-of-Care Syphilis Testing; Revised Urinary Catheter Use Guidelines; HIV and Meningococcal Vaccination Revisited