Internal Medicine
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SGLT2 Inhibitors: Now The Bad News
Sodium-glucose cotransporter-2 inhibitors are approved as adjunctive therapy for the treatment of patients with type 2 diabetes. This drug class has been also used off-label to improve glycemic control in patients with type 1 diabetes.
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ECG Review: Is There Complete AV Block?
The simultaneously-recorded 3-lead rhythm strip in the figure was obtained from a 75-year-old woman who presented to the emergency department with syncope. She was diagnosed as being in complete (third-degree) AV block. Do you agree with this interpretation?
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Clinical Briefs
Treating symptomatic venous thromboembolism with warfarin; extending the window of anticoagulation after pulmonary embolus; and stroke accelerates long-term process of cognitive decline.
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Sacubitril and Valsartan Tablets (Entresto)
A new option for heart failure incorporates two drugs with different mechanisms of action.
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Antibiotics for Acute Appendicitis
A randomized, multicenter clinical trial compared antibiotic therapy to surgery for uncomplicated acute appendicitis and found most patients who received antibiotics did not require appendectomy during the 1-year follow-up period.
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Are Premature Ventricular Contractions Dangerous?
A higher frequency of premature ventricular contractions was associated with a decrease in left ventricular ejection fraction, an increase in incident congestive heart failure, and an increase in mortality.
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The Spice of (Prolonged) Life
ABSTRACT & COMMENTARY: Habitual consumption of spicy foods is associated with reduced mortality independent of other risk factors for death. Hot stuff!
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Infectious Disease Alert Updates
TB Screening for High-Tech Workers
Cellulitis or Pseudocellulitis?
Screening for Creutzfeldt-Jakob Disease Before Invasive Procedures
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Influenza Vaccination: Updated Information for 2015-16
The CDC has published updates of last year’s recommendations of the Advisory Committee on Immunization Practices for the use of seasonal influenza vaccines. The following is a selection of some of the most pertinent ones.
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Scrub Typhus and the Brain
Scrub typhus infections involve the nervous system in a majority of cases and should be suspected in patients who live in, or are returning from, endemic regions with a compatible clinical syndrome.