Internal Medicine
RSSArticles
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Chronic Obstructive Pulmonary Disease: Update
Over the past decade, this definition of COPD has changed dramatically, as has the characterization and treatment of individuals with COPD. Multiple new therapies alter the course of this disease, reduce exacerbations, improve quality of life, and increase survival; previous nihilistic approaches to the management of COPD have been replaced by directed and effective pharmacologic and nonpharmacologic therapies. This update will review current approaches to the diagnosis and management of COPD and present the most recent evidence for the classification of COPD phenotypes and the implications of these categories for COPD treatment and prognosis.
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Every 5-minute Delay in Performing Endovascular Reperfusion Results in 1 out of 100 Patients Having a Worse Disability Outcome
Every 5-minute delay in performing endovascular reperfusion results in 1 out of 100 patients having a worse disability outcome.
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Treatment for Ulnar Neuropathy at the Elbow
In a randomized treatment trial of steroid injection into the cubital tunnel for ulnar neuropathy, there was no difference in outcome compared to placebo.
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Botulinum Toxin and Treatment of Spasticity
AbobotulinumtoxinA is effective at reducing spasticity and reducing disability in patients with upper limb spasticity due to stroke or traumatic brain injury.
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Lower Risk of Parkinson’s Disease After Vagotomy: Implications for Spread of Pathology
Truncal vagotomy was associated with a reduced risk for Parkinson’s disease with a hazard ratio of 0.58 for those with more than 20 years’ follow-up. This suggests the vagus nerve as a possible route of entry into the central nervous system for this neurodegenerative process.
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Potential Imaging Biomarkers of SUDEP: Can We Predict Sudden Death in Epilepsy?
The authors retrospectively conducted a voxel-based analysis of T1 MRI scans to compare gray matter volumes in 12 cases of sudden unexpected death in epilepsy (SUDEP) acquired at a median of 2 years before death with patients at high or low risk for SUDEP and with healthy controls, and demonstrated significant anatomical differences between the groups.
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Autoimmune Cerebellar Ataxia — Responses to Treatment
This study analyzed patients diagnosed with antibody-mediated paraneoplastic and non-paraneoplastic cerebellar ataxia, and treatment benefit was seen predominantly in the non-paraneoplastic group.
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Collaborative Care for Children with ADHD Symptoms: A Randomized Comparative Effectiveness Trial
Strengthening collaborative care improves reduction of ADHD symptoms in a population of inner-city, low-income children.
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Aspergillus niger-derived Prolyl Endoprotease Improves Gluten Degradation
A prolyl endoprotease derived from Aspergillus niger has been shown to be capable of degrading gluten at the level of the stomach from both low- and high-calorie meals, minimizing duodenal and small intestine exposure to gluten. The use the prolyl endoprotease enzyme lowered α-gliadin concentration in the stomach and duodenum and absolute α-gliadin exposure in the duodenum over 240 minutes after consumption of a gluten-containing meal.
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The Safety of Yoga
These authors performed a systematic review of the literature to ascertain the safety of yoga and found that yoga is not associated with an increased frequency of nonserious or serious adverse events compared with usual care or exercise.