Internal Medicine
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Spironolactone for Resistant Hypertension
ABSTRACT & COMMENTARY: A study says spironolactone is superior to doxazosin and bisoprolol for lowering blood pressure.
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Clinicians Are Skeptical of Early Warning Systems for Sepsis
While early warning systems for sepsis lead to clinical action, clinicians are skeptical and do not perceive them to be beneficial.
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Bedside Ultrasound: Is It a Reliable Tool for Guiding Resuscitation in Patients with Undifferentiated Hypotension?
The use of bedside ultrasound for patients with undifferentiated hypotension in the emergency department substantially changed the plan of care and reduced physician diagnostic uncertainty.
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Initial Choice of Fluid for Sepsis Resuscitation May Affect Mortality
The use of balanced salt solutions rather than isotonic saline or colloids may improve in-hospital mortality in patients admitted with septic shock.
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Open Lung Biopsy in Critically Ill Patients
ABSTRACT & COMMENTARY: The procedure is associated with complication of persistent air leak and a significant hospital mortality of 54%.
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Clinical Briefs
In this section: no payoff to physical therapy after healed ankle fracture; bisphosphonates and bone recurrence; and manipulating the microbiome.
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No More Bacon? Carcinogenicity of Meat
A review of published research by the World Health Organization concludes that processed meats are probably carcinogenic.
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Naloxone Nasal Spray (Narcan)
The FDA has approved naloxone in the form of a nasal spray as a life-saving medication to reverse the effects of an opioid overdose.
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Nicotinamide Chemoprevention for Skin Cancer Is Impressive
In a Phase III, double-blind, randomized, placebo-controlled trial, oral nicotinamide was safe and effective in reducing the rates of new nonmelanoma skin cancers and actinic keratoses in high-risk patients.
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Vitamin D Levels and Cognitive Function: Does It Make a Difference?
Similar to previous studies, vitamin D deficiency and insufficiency rates were not significantly different between those with normal cognitive status, mild cognitive impairment, or dementia. However, cognitive decline occurred at a significantly greater rate in individuals with low 25-hydroxyvitamin D levels in the areas of episodic memory and executive function.