Internal Medicine
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High Blood Pressure: How Low Should We Go? SPRINT and a New Meta-analysis
A recent meta-analysis supports the benefit of targeting lower blood pressure levels.
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ECG Review: What Has Happened in 8 Minutes?
The ECG in the figure illustrates how rapidly ST-T wave changes may develop during active stages of acute ST elevation myocardial infarction. In this case, no more than 8 minutes was necessary for the ECG to evolve from a minimally abnormal tracing to the dramatic picture of diffuse ST-T wave changes.
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Clinical Briefs
In this section: The measurement of C-reactive protein in hidradenitis patients may enhance assessment of disease severity; studying the relationship between gut flora and mood disorders; and weighing the benefits of administration of pre-exposure prophylaxis immediately before and after sexual activity.
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Lesinurad Tablets (Zurampic)
Lesinurad is a drug with a different mechanism of action to augment the action of a xanthine oxidase inhibitor, resulting in additional reduction of serum uric acid levels.
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Why Dentists Are Suddenly Smiling
In this meta-analysis of 51 randomized, controlled studies that included nearly 5000 patients, continuous positive airway pressure and oral appliances resulted in comparable and statistically significant reductions in blood pressure.
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Diabetes, Dementia, and Hormones
Higher levels of estrogen may exacerbate risks that type 2 diabetes pose for cognitive function decline in older women.
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Infectious Disease Alert Updates
Diagnostic Puzzle? Solved by The New York Times; Glucometers as Culprit; Shorter Isolation Times for TB
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Clinicians Are Skeptical of Early Warning Systems for Sepsis
While early warning systems for sepsis lead to clinical action, clinicians are skeptical and do not perceive them to be beneficial.
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Posaconazole Dosing — Beware!
The availability of two different oral formulations of posacozaole (oral suspension, delayed release tablets) with differing bioavailability and dosing requires great care by both prescribers and dispensing pharmacists in their use.
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Bronchiolitis
Bronchiolitis is a common infection caused by several different viruses; 20% of children in the United States seek medical care for respiratory syncytial virus , a common cause of bronchiolitis, during the first year of life. Supportive care is effective, but many children still receive pharmacologic treatments that have been proven to be ineffective.