Internal Medicine
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Nitrate Therapy Shows Possible Harm in Heart Failure with Preserved Ejection Fraction
In heart failure with preserved ejection fraction, the use of isosorbide mononitrate was associated with a nonsignificant decrease in physical activity level, and no improvement in symptoms or quality of life.
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The Portal of Bacterial Entry in Infective Endocarditis
ABSTRACT & COMMENTARY: A comprehensive, systematic search for the portal of bacterial entry in infective endocarditis is frequently successful.
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Does the Use of Saline vs Buffered Crystalloid Reduce Risk of Acute Kidney Injury in ICU?
The use of a buffered crystalloid compared with saline did not reduce the risk of acute kidney injury in patients receiving crystalloid fluid therapy in the ICU.
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Effects of a Rapid Response System Driven by Real-time Automated Clinical Alerts on Hospital Mortality and Length of Stay
The addition of an automated real-time clinical deterioration alert system to a rapid response system had marginal effects.
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New Insights Into Alveolar Mechanics and Gas Exchange in Experimental Acute Respiratory Distress Syndrome
Experimental acute respiratory distress syndrome was induced in mice to study local alveolar gas dynamics using advanced microimaging techniques. Heretofore unrecognized disturbances in alveolar ventilation will alter our understanding of alveolar mechanics and gas exchange dysfunction as well as promote the use of recruitment maneuvers.
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Swallowing Dysfunction in Critical Illness
Maintaining a high index of suspicion for the presence of possible swallowing dysfunction is key for the clinician.
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Clinical Briefs
In this section: another reason to take vitamin D supplements; polishing physical exam skills; and comparing the relationship between uric acid, fructose, and hypertension.
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Elbasvir and Grazoprevir Tablets (Zepatier)
The FDA has approved another oral interferon-free regimen for the treatment of chronic hepatitis C (HCV) genotypes 1 and 4.
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Should Postmenopausal Women Be Encouraged to Take Calcium?
A systematic review of randomized, controlled trials of calcium supplementation found only small non-progressive increases in bone mineral density. This supports the clinical conclusion that supplementation alone is insufficient to prevent fracture risk.
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Association of Coffee Consumption with Total and Cause-specific Mortality
Regular consumption of both caffeinated and decaffeinated coffee were found to be inversely associated with risk of total mortality and mortality attributed to cardiovascular disease and neurologic diseases.