Internal Medicine
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Nitrate Therapy Shows Possible Harm in Heart Failure with Preserved Ejection Fraction
In heart failure with preserved ejection fraction, the use of isosorbide mononitrate was associated with a nonsignificant decrease in physical activity level, and no improvement in symptoms or quality of life.
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Does Finding the Portal of Entry of Bacteria in Infective Endocarditis Matter?
A comprehensive, systematic search for the portal of bacterial entry in infective endocarditis is frequently successful and affords an opportunity to prevent recurrent episodes.
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Does the Use of Saline vs Buffered Crystalloid Reduce Risk of Acute Kidney Injury in ICU?
The use of a buffered crystalloid compared with saline did not reduce the risk of acute kidney injury in patients receiving crystalloid fluid therapy in the ICU.
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Effects of a Rapid Response System Driven by Real-time Automated Clinical Alerts
The addition of an automated real-time clinical deterioration alert system to a rapid response system had marginal effects.
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Integrative Approaches to Alzheimer’s Disease
The medical community had warning. “Dementia in the Elderly: The Silent Epidemic,” a 1982 Annals of Internal Medicine landmark article, looked at the “greying of America” and noted one natural consequence of longer life span would be an explosive impact on the prevalence of dementia. Indeed, the epidemic has come — not only in the United States, but also globally, with dementia affecting an estimated 46 million people worldwide in 2015 and projected to affect 131 million by 2050.
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Mind Over (Back Pain) Matter: An RCT
Mindfulness meditation training led to greater short-term function and less pain in adults with chronic low back pain when compared to a control group receiving only educational sessions.
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Prenatal Exercise for Pregnancy-induced Hypertension and Weight Gain
Regular exercise throughout pregnancy wards off hypertension and excessive gestational weight gain without increasing the incidence of low birthweight infants.
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A Brief Report of Clinical Trials Results from the 2016 International Stroke Conference
This article provides an overview of the research presented at the 2016 International Stroke Conference.
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Hypoxia-induced Migraine
Hypoxia-induced migraine attacks with and without aura, in an experimental paradigm, were accompanied by dilation of cranial arteries in individuals who have migraine with aura, as well as in healthy control subjects.
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Predicting Seizure Recurrence with Routine EEG after First Unprovoked Seizure
The authors systematically reviewed prospective and retrospective studies of adults and children undergoing routine electroencephalography (EEG) after a first unprovoked seizure who were followed for at least 1 year. Using positive likelihood ratios, an adult and child with epileptiform discharges on EEG were estimated to have a 77% and 66% probability, respectively, of recurrent seizures.