Internal Medicine
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Is Weight Loss the Key to Heart Health?
The second trial of semaglutide in obese patients with heart failure and preserved left ventricular ejection fraction, this one in people with type 2 diabetes, also has shown significant improvements in symptoms and exercise function with significantly fewer adverse effects than placebo-treated patients.
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It Is Never Too Late: A Systematic Review of Lifestyle Interventions for Cognitive Preservation in the Oldest-Old
This systematic review reveals the importance of a healthy diet rich in fruits and vegetables, along with regular leisure and physical activities, to maintain cognitive functioning in the oldest-old, individuals older than 80 years of age.
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A Run of Aberrant AFib?
The patient whose electrocardiogram (ECG) appears in the figure is a previously healthy man who presented to the emergency department because of acute dyspnea. What is the cause of the run of wide beats?
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Aprocitentan (Tryvio)
The U.S. Food and Drug Administration (FDA) has approved a first-in-class endothelin receptor antagonist for the treatment of high blood pressure not adequately controlled with other antihypertensives.
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The Globe May Be Warming, but People Are Cooler
What is normal? Patients like to tell me their normal temperature is “not normal.” Our idea of a normal temperature came from the work of a German physician who screened 25,000 patients and concluded in an 1868 publication that the normal human body temperature was 98.6°F. That number has stuck with us for 150 years. Are people now cooler?
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Rapid Reversal of Anticoagulation Reduces Mortality from Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) is the deadliest type of stroke. ICH associated with anticoagulation carries an even higher mortality. Serial imaging studies have demonstrated that there is significant hematoma enlargement during the first few hours after arrival at the hospital, and this also portends a poor outcome.
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Stress Reduction for Physicians — What Works?
A randomized controlled study of 129 physicians demonstrated that a two-month regimen of sudarshan kriya yoga, incorporating stretching, breathing, and meditation, is associated with reduced stress, anxiety, and depressive symptoms when compared to conventional stress management training.
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Does Calcium Intake Cause Cardiovascular Disease?
A large population study of calcium intake at dinner vs. breakfast showed an increased risk of heart disease.
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Ceftobiprole Medocaril Sodium for Injection (Zevtera)
The U.S. Food and Drug Administration has approved a new cephalosporin antibacterial for the treatment of three serious infections: bloodstream, skin and skin structure, and community-acquired pneumonia. Ceftobiprole is a fifth-generation cephalosporin with in vitro activity against gram-positive and gram-negative bacteria including multidrug resistant organisms. It will be distributed by Basilea Pharmaceutica International Ltd, Allschwil as Zevtera.
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Another Step in the Journey to Combat Diagnostic Errors in Hospitalized Patients
Diagnostic errors in hospitalized patients who died or were transferred to the intensive care unit were common in this large retrospective, multicenter trial and frequently associated with patient harm. Problems with clinical assessment and ordering and interpreting tests were the most prevalent diagnostic process faults, with sepsis the diagnosis most associated with diagnostic error.