Internal Medicine
RSSArticles
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EEG Reactivity Testing in Comatose Patients After Severe Brain Injury
Studies assessing EEG reactivity in comatose patients after severe brain injuries are highly variable and almost never provide replicable definitions for presence or absence of EEG reactivity, even though it is used increasingly as a prognostic measure.
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Guillain-Barré Syndrome and Hepatitis E
Hepatitis E is the most common form of viral hepatitis worldwide and often is asymptomatic. But it is commonly associated with Guillain-Barré syndrome and Guillain-Barré variants.
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Differences in Disease Duration in LBD May Be Related to Pathologic Burden
This observational study of 807 autopsy-confirmed cases of Lewy body disease used Braak neurofibrillary tangle staging, frequency of neuritic plaques, and Lewy body staging to demonstrate that those individuals who had diffuse LBD had a shorter disease duration than those with transitional LBD localized to the limbic region.
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Ocrelizumab for Multiple Sclerosis
A Phase III trial of ocrelizumab in primary-progressive multiple sclerosis and two Phase III trials of ocrelizumab in relapsing-remitting multiple sclerosis have demonstrated efficacy with treatment.
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New Tools for the Diagnosis of CJD
Cerebrospinal fluid analysis using second-generation, real-time, quaking-induced conversion has a high sensitivity and specificity for the diagnosis of Creutzfeldt-Jakob disease.
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Troponin Highly Prognostic in Decompensated Heart Failure with Preserved Ejection Fraction
SYNOPSIS: Among patients with acute decompensated heart failure and preserved ejection fraction, elevated troponin is associated with worse in-hospital outcomes and long-term survival, independent of other predictors.
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NOACs in Patients Requiring Anticoagulation Post-PCI
SYNOPSIS: The PIONEER study of atrial fibrillation patients post-percutaneous coronary intervention showed that regimens of clopidogrel plus reduced-dose regimens of rivaroxaban demonstrated lower bleeding and similar rates of stroke and adverse cardiac events compared with traditional warfarin triple therapy.
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A New Risk Score for Stroke in Atrial Fibrillation
SYNOPSIS: A new, simpler score for stroke risk prediction in atrial fibrillation patients uses biomarkers to supplant many clinical variables and outperforms the CHA2DS2-VASc score in two large cohorts.
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Antibiotic Treatment in Community-acquired Pneumonia
SYNOPSIS: In patients with newly diagnosed community-acquired pneumonia, basing the duration of antibiotic treatment on clinical stability criteria led to a significant reduction in duration of antibiotic treatment without an increased risk of adverse outcomes.
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Discharge Antibiotic Prescriptions Often Are Inappropriate with Regard to Choice, Dose, Duration
SYNOPSIS: Seventy percent of discharge antibiotic prescriptions are inappropriate.