Internal Medicine
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A Novel Target for Migraine Prevention Through Modulation of Stress Receptors
Kappa opioid receptors (KORs) modulate response to stress, a common migraine trigger, so KOR blockade may be a novel preventive treatment for migraine as well as other stress-related diseases.
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Outcomes After Surgical Treatment of Nonlesional Neocortical Epilepsy
In this study of 109 consecutive patients with medically refractory neocortical epilepsy without MRI-identifiable lesions who underwent focal resection at a single hospital from 1995 to 2005, almost 60% of patients achieved long-term seizure freedom, with anti-epileptic drugs being withdrawn successfully in about a third of these patients.
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Bright-light Therapy for Daytime Sleepiness in Parkinson’s Disease Patients
Light therapy has been shown to be beneficial in treating excessive daytime sleepiness in Parkinson’s disease patients and also may improve sleep quality.
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Fludrocortisone for Orthostatic Hypotension Associated With Parkinson’s Disease
This double-center, double-blind, randomized, controlled trial compared the efficacy of pyridostigmine bromide vs. fludrocortisone and demonstrated that pyridostigmine bromide was not as effective as fludrocortisone. The authors also provided evidence for the efficacy of fludrocortisone in treating neurogenic orthostatic hypotension.
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Rituximab for Myasthenia Gravis
In uncontrolled, observational case series, rituximab treatment for myasthenia gravis appears to be effective and safe, but more studies are needed for confirmation.
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Blood-brain Barrier Breakdown in RCVS
In this single-center, prospective trial, patients with reversible cerebral vasoconstriction were found to have evidence of blood-brain barrier breakdown on MRI.
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Beetroot Juice and Aerobic Endurance and Blood Pressure
Researchers found that drinking beetroot juice daily improves submaximal aerobic endurance in patients with cardiac failure and preserved ejection fraction.
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Low Back Pain: Evidence for Nonpharmacologic Therapies
Developed for use in the new American College of Physicians guidelines, the authors reviewed evidence regarding non-pharmacologic interventions in treatment of low back pain.
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Insomnia Disorder: Evidence for Psychological and Behavioral Interventions
Cognitive behavioral therapy for insomnia (CBT-I) is an effective intervention for moderate to severe insomnia disorder and should be considered as an initial treatment.
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Tai Chi for Knee Osteoarthritis
Tai chi is as effective as a standard course of physical therapy in the treatment of pain of osteoarthritis of the knee.