Internal Medicine
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Tai Chi and Fall Risk
Tai chi practice in the older and at-risk population reduces the risk of falls (with the most robust results in the short-term) and may reduce the risk of injury from falls; no effect is seen when measuring time to the first fall.
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Secnidazole Oral Granules (Solosec)
The FDA has approved the first oral single-dose treatment for bacterial vaginosis in adult women.
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Etiology of Acute Liver Failure and Next-generation Sequencing
Metagenomic next-generation sequencing was applied to examine serum from 204 adult patients with acute liver failure (ALF). Researchers identified a potential viral etiology in eight of the 187 patients with ALF of indeterminate etiology. Potential pathogens identified in these included HSV-1, HBV, parvovirus B19, CMV, and HHV-7.
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Do Antibiotics Reduce Hormonal Contraceptive Effectiveness?
This is a systematic review of studies evaluating the effect of concomitant non-rifamycin antibiotics use on hormonal contraceptive effectiveness. Although data are limited, there is no evidence to support the existence of drug interactions.
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Stewardship, Science, and Spirituality
Awareness of a patient’s and family’s belief system might help physicians appropriately frame explanations about the importance of antimicrobial stewardship.
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Meropenem-vaborbactam
Meropenem-vaborbactam (Vabomere) is the latest β-lactam/β-lactamase inhibitor (BLI), approved by the FDA in August 2017 for treatment of complicated urinary tract infections (cUTI), including pyelonephritis, caused by susceptible Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae species complex in adults older than 18 years of age.
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Patent Foramen Ovale Intervention Rises to Occasion in Cryptogenic Stroke
After years of uncertainty, three large randomized trials have shown a benefit to patent foramen ovale closure in reducing recurrence after cryptogenic stroke in the right patients.
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In-hospital vs. Telephone Availability of an Intensivist at Night
When overnight shifts were staffed by nighttime intensivists rather than residents with attending intensivists on call remotely, most nurses perceived improvements in clinical care, procedures, efficiency, communication, and job place comfort.
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Antibiotics and Adverse Events: Doctors, Do No Harm!
A retrospective study found that among 1,488 hospitalized patients who received an antibiotic, 298 (20%) experienced at least one antibiotic-associated adverse drug event.
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Statin Use Is Associated With a Lower Risk of Community-acquired Staphylococcus aureus Bacteremia
A population-based case-control study from Denmark found the use of statins was associated with a decreased risk for community-associated Staphylococcus aureus bacteremia, with the greatest benefit from higher doses.