Internal Medicine
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Systemic Immune Activation and the Course of Amyotrophic Lateral Sclerosis
Activation of the immune system has been recognized in patients with amyotrophic lateral sclerosis, and immune activation may influence the course of the disease and the speed of progression.
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Optimizing Brain Oxygen in Severe Traumatic Brain Injury
In a Phase II, single-blind, randomized, multicenter trial, the use of intraparenchymal brain tissue oxygenation monitoring reduced brain tissue hypoxia in patients with severe traumatic brain injury.
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MRI-guided FUS Thalamotomy for Medically Refractory Parkinson’s Tremor
This study comparing 20 individuals who received MRI-guided focused ultrasound thalamotomy with seven individuals who received sham treatment showed improvements in Parkinson’s disease tremor. Side effects were similar to prior studies of this technology for essential tremor, with ataxia and limb/orofacial paresthesias being most common.
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Neurologic Consequences of Zika Virus Infection
Neurologic sequelae of Zika virus infections include Guillain-Barré syndrome, encephalitis, transverse myelitis, and chronic inflammatory demyelinating polyneuropathy.
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Treatment for Spinal Muscular Atrophy
In a randomized, double-blind, sham-controlled study of infants with spinal muscular atrophy (SMA) type 1, nusinersen treatment led to significant improvement in motor milestones and survival without significant adverse reactions. A safety trial of gene therapy for SMA type 1 demonstrated prolonged ventilator-free survival and improved motor milestones with minimal side effects.
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What Do You Know About Wound Care?
This article will summarize the salient features of wound care, including demographics of a changing population, fundamental phases of wound healing, advances in therapeutic modalities, and steps family physicians can take to become recognized as certified wound care physicians.
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Topical Cannabis for Wound Pain: A Case Series
For three people with continued pain despite conventional treatment for pyoderma gangrenosum, topical cannabis led to statistically significant pain relief for two of them.
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Low Serum 25-hydroxyvitamin D and Risk of Frequent Headache
Low vitamin D levels are associated with a range of neurovascular diseases, but little data are available on the association between vitamin D levels and headaches. This retrospective, cross-sectional study showed that low serum vitamin D levels were associated with a higher risk of frequent headaches in middle-aged/elderly Finnish men.
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Black seed (Nigella sativa) for Asthma: Minimal Effects
SYNOPSIS: Black seed, crushed, in capsule form, administered to 76 people with asthma in a single-blind, randomized study, showed some minimal improvements in some, but not all, components of spirometry and one serum cytokine after 12 weeks.
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Use of Essential Oils as an Alternative Treatment for Depression
The antidepressant effects of essential oils are promising, but more studies in humans beyond preliminary stages are needed.