Internal Medicine
RSSArticles
-
Lessons Learned From a Failed Anti-amyloid Trial for Alzheimer’s Disease
Despite the disappointing results in EXPEDITION 3, modifications of clinical trials for Alzheimer’s disease (AD) should be undertaken and trials targeting preclinical or early AD should continue with anti-amyloid agents.
-
Postpartum Headache May Be a Symptom of a Serious Problem
Consultation for acute postpartum headache resulted in the diagnosis of a secondary cause of headache in almost three out of four women, with almost half of the secondary headaches due to a hypertensive disorder of pregnancy or to cerebrovascular disease.
-
Coprescription of Triptans and SSRI-type Medications and the Serotonin Syndrome
A recent study provided reassurance that the use of triptan antimigraine medications with selective serotonin reuptake inhibitor and selective norepinephrine reuptake inhibitor antidepressants is safe.
-
Autoimmune Encephalitis: Not Rare and Increasing
Detection of autoimmune encephalitis is increasing over time. According to the results from this population-based study, its prevalence and incidence are comparable to infectious encephalitis.
-
Infectious Disease Alert Updates
Online Sex and Sexually Transmitted Diseases; Swingers Come Out; HIV-positive Patients Require Hepatitis B Vaccine
-
Adjuvanted Recombinant Hepatitis B Vaccine (Heplisav-B)
Heplisav-B is a new hepatitis B vaccine approved by the FDA in November 2017.
-
Influenza Vaccine: High Dose or Standard Dose?
High-dose inactivated influenza vaccine was superior to standard-dose vaccine in providing protection against influenza or pneumonia-associated hospitalizations.
-
Refugee Screening
Screening and potential treatment of refugees prior to travel to the United States effectively reduces the burden of infection.
-
SIRS Criteria vs. qSOFA for Predicting Short-term Mortality From Sepsis
A meta-analysis that included 38 studies found the SIRS criteria had a higher sensitivity than qSOFA in predicting short-term mortality from sepsis. SIRS criteria remain useful as a screening tool for sepsis and as a prompt to initiate diagnostic work-up and treatment.
-
Neuroimaging Before Lumbar Puncture?
The investigators retrospectively evaluated ESCMIID, IDSA, and Swedish guidelines for neuroimaging in 815 adults with acute bacterial meningitis. Swedish guidelines omit altered mental status and immunosuppression as indications for imaging prior to lumbar puncture. Adherence to Swedish guidelines resulted in decreased mortality and more favorable outcomes.