Internal Medicine
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Does Triple Inhaled Therapy for COPD Decrease Exacerbations Compared to Dual Therapy?
A single dose of inhaled triple therapy improved exacerbations compared to dual therapy in COPD patients.
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Cannabidiol for Pediatric Seizures
Three months of cannabidiol-enriched cannabis extract decreased mean monthly seizure frequency in children and young adults with refractory epilepsy.
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Vitamin D and Glycemic Control in Patients with Type 2 Diabetes
Findings from a meta-analysis show vitamin D supplementation was associated with improved glycemic control in vitamin D-deficient or non-obese patients with type 2 diabetes.
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Is There a Link Between Stopping Exercise and Depressive Symptoms?
SYNOPSIS: The authors of this review article found a suggestive link between stopping exercise and the onset of depressive symptoms in healthy adults, especially in women.
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Probiotic Use in Day Care Children
A 12-week intervention of daily supplementation with probiotics Bifidobacterium animalis subsp. lactis (BB-12) and Lactobacillus rhamnosus (LGG) 10 billion colony-forming units produced no reduction in the number of days absent from day care in Danish infants 8 to 14 months old.
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A Contemporary Review of Hypertension
Hypertension is a common and serious condition that contributes to an estimated 40% of deaths from coronary heart disease and stroke, and is the second leading cause of end-stage renal disease. Because of the importance and frequency of hypertension in primary care practices, we are devoting two issues to the subject. This issue focuses on the definition of blood pressure and current guidelines, risk factors, relationship to cardiovascular disease, blood pressure measurement, patient evaluation, and secondary causes. The next issue will cover treatments (pharmacological and non-pharmacological), initial therapy, relationship to various disease conditions (diabetes, ischemic heart disease, heart failure, chronic kidney disease, cerebrovascular disease, ischemic stroke, stroke prevention, atrial fibrillation, valvular heart disease, aortic regurgitation, sexual dysfunction), resistant hypertension, hypertensive crises and emergencies, preoperative management, and adherence strategies.
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Untangling the Factors Governing Huntington’s Disease Progression
In a study of more than 3,000 subjects, CAG-repeat-dependent factors affecting age at onset also influenced rates of progression of cognitive, motor, and functional impairments, providing optimism that developing interventions, such as gene silencing therapies, could provide benefit.
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Predicting Future Dementia With Retinal Optical Coherence Tomography
Optical coherence tomography (OCT) is an innovative imaging device that measures thickness of retinal nerve fiber layers and ganglion cells. Thinning of these layers is associated with current and future risk of dementia.
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Use of Amyloid PET Imaging for Diagnosis of Dementia
The use of amyloid positron emission tomography scanning to assist in accurate diagnosis of patients with symptoms of cognitive impairment as well as frank dementia results in a change of diagnosis in at least 25% of patients.
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Viral Therapy for Glioblastoma
In a Phase I/II trial, convection-enhanced delivery of an engineered poliovirus yielded similar median overall survival compared to historical controls. However, a small subgroup of treated patients had extended survival past two years.