Internal Medicine
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Testing Safety, Efficacy of Pharmacotherapy in Hospitalized Heart Failure Patients
In patients hospitalized for acute decompensated heart failure with reduced ejection fraction, administering sacubitril-valsartan led to more improvement in levels of cardiac biomarkers compared to enalapril, with no adverse safety signals.
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PCSK9 Inhibitors in Acute Coronary Syndrome Patients
Compared to adding placebo, using the proprotein convertase subtilisin/kexin type 9 inhibitor alirocumab in post-acute coronary syndrome patients on maximally tolerated, high-intensity statins with low-density lipoprotein (LDL) cholesterol levels higher than 70 mg/dL lowered LDL and reduced the number of major adverse cardiac events.
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Infectious Disease Alert Updates
Circulation of a Novel Vaccinia Virus in Brazilian Equids; Chopin’s Brandied Heart; The Scent of Malaria
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Antibiotic Decision-Making Between Medical and Surgical Teams
In an observational study conducted at an academic medical center in London, researchers looked at factors involved in decision-making. The presumptive diagnosis of infection by the emergency department (ED) influenced decision-making by both medical and surgical admitting teams. Medical teams tended to use a multidisciplinary approach to antibiotic decision-making. Surgical teams often delegated antibiotic decision-making to the most junior members of the surgical team.
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Acute Flaccid Myelitis 2018
The number of reported cases of acute flaccid myelitis, a paralytic disease of unknown etiology, has increased.
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Preventing Clostridioides difficile Infections: Early De-escalation of Antipseudomonal Antibiotics
Early discontinuation of empirically administered antipseudomonal antibiotics may prevent many cases of Clostridioides difficile infection.
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The Longhorned Tick: Is It Coming to a Place Near You?
A tick that can transmit several infections has been newly identified in the United States.
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Omadacycline Injection and Tablets (Nuzyra)
The FDA has approved a broad-spectrum antibiotic for the treatment of community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections.
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Should Acute Appendicitis Be Managed Without Appendectomy?
A retrospective cohort study that used national insurance claims data found patients with acute appendicitis who were treated nonsurgically had higher rates of complications and higher overall cost of care.
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Is Sanitizer Better Than Soap?
In day care settings, the implementation of hand hygiene programs reduced respiratory illness, absenteeism, and antibiotic use in children 0 to 3 years of age. Using hand sanitizer was more effective than washing with soap and water.