Internal Medicine
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Neuropathy in Systemic Lupus Erythematosus
Systemic lupus erythematosus may be associated with a variety of neuropsychiatric syndromes, including peripheral neuropathy, mostly sensorimotor types. However, all parts of the peripheral and central nervous system may be affected; careful and repeated neurological evaluation is important.
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Sacubitril-Valsartan Reduces Functional Mitral Regurgitation
In patients with chronic heart failure and functional mitral regurgitation, sacubitril/valsartan was associated with greater reduction in mitral regurgitation compared to valsartan alone.
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Workplace Violence, Bullying Associated With Cardiovascular Disease Risk
In a 12-year follow-up of surveyed Scandinavian employees, reported workplace violence and bullying increased the risk of future cardiovascular disease of a magnitude similar to other recognized cardiovascular disease risk factors.
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Are Calcium Channel Blockers Needed for Radial Artery Grafts?
A combined analysis of six trials comparing radial artery grafts vs. saphenous vein grafts for coronary bypass surgery revealed that patients taking calcium channel blockers for at least one year experienced fewer major cardiac events and fewer radial graft occlusions than those not so treated.
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Mildly Elevated Pulmonary Arterial Pressure Associated With Higher Mortality Rate
In a large cohort of patients referred for echocardiography, an estimated right ventricular systolic pressure > 30 mmHg was associated with higher mortality rates.
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Is Earlier Better With Oral P2Y12 Inhibition in STEMI Patients?
In a large retrospective analysis of patients in Sweden treated with primary percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction, a propensity-matched group of patients who received oral P2Y12 inhibitors at initial medical contact did not show improved outcomes vs. those receiving these agents at the time of PCI.
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Early vs. Delayed Cardioversion: A Nonshocking Result
For patients presenting to an ED with recent-onset atrial fibrillation, using rate control and outpatient cardioversion only as needed was associated with a high rate of spontaneous conversion within 48 hours of arrhythmia onset and noninferior short-term outcomes compared to immediate cardioversion in the ED.
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Efficacy of Preoxygenation Methods Prior to Endotracheal Intubation
A post-hoc analysis of data from the MACMAN trial revealed noninvasive ventilation may be the preferred preoxygenation approach for intubation, especially in the setting of severe hypoxemia.