Internal Medicine
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Antiplatelet Agents Plus Oral Anticoagulants in Atrial Fibrillation
In patients with stable coronary artery disease and atrial fibrillation (AF) on oral anticoagulants, adding antiplatelet agents is common and recommended in guidelines, especially during the first year after an acute coronary event or revascularization. -
Current Utility of Exercise ECG Testing
Most current guidelines recommend exercise electrocardiographic (ECG) testing for suspected coronary artery disease (CAD) in patients who can exercise and have a normal resting ECG. -
Long-Term Benefits of Cardiac Resynchronization Therapy in Patients with Left Bundle Branch Block
The Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy (MADIT-CRT) showed that implantation of a cardiac-resynchronization therapy with a defibrillator (CRT-D) in patients with left bundle-branch block (LBBB), Class I or II congestive heart failure (CHF), and an ejection fraction < 30% was associated with a significant reduction in heart-failure events over 2.4 years. -
Neuropathy with Hepatitis C Virus-Related Cryoglobulinemia
Most patients who develop cryoglobulinemia associated with hepatitis C infection will develop symptoms and signs of a symmetric, distal sensory neuropathy. -
Trochlear Headache: A Rare, Specific 'Eye-strain' Headache
Trochlear headaches should be considered in patients with new onset, constant, unilateral eye pain, especially when the pain is aggravated by eye movement. -
Pesticides and Development of Alzheimer’s Disease — New Evidence
A new case-control study finds that increased levels of dichlorodiphenyldichloroethylene (DDE), which is the metabolite of the pesticide dichlorodiphenyltrichloroethane (DDT), are associated with an increased risk for Alzheimer's disease. -
MRI as a Biomarker for Hippocampal Injury in Febrile Status Epilepticus
In this prospective study, the authors use brain imaging criteria to determine whether acute febrile status results in acute hippocampal injury and potentially chronic hippocampal sclerosis. -
Stroke Alert: A Review of Current Clinical Stroke Literature
What is the Best Treatment for Cerebral Cavernous Malformations? -
Cerebrospinal Fluid ß-Amyloid 42 vs Amyloid PET Imaging in the Diagnosis of Alzheimer’s Disease
Aß 42, measured in cerebrospinal fluid, may help determine whether patients have normal or increased cortical Aß deposition. Additionally, abnormal PET 18F-flutemetamol retention levels correlate with disease stage in patients with mild cognitive symptoms.
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Varicella-Zoster Virus and Fingolimod: Much Ado about Not Much?
The risk of varicella-zoster virus infections in patients treated with fingolimod is slightly higher than placebo, but is overall quite low.