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This pilot study reports that dexmedetomidine might be the sedative of choice for less ill mechanically ventilated ICU patients who take antidepressant medications at home.
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Hospital-based infection surveillance experts nationwide participated in a survey to access the level of agreement in diagnosing ventilator-associated pneumonia by evaluating six identical case studies. The level of agreement between participants was poor.
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In this large observational study in four hospitals with a standardized rapid response system, among patients with an initial team activation who were not immediately transferred to the ICU, those with one or more additional activations during the hospitalization were more likely to need ICU care and had both longer hospital stays and higher mortality.
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In this prospective study of older ICU patients (mean age, 67 years), frailty as assessed by a simple scale was present in one-third and was strongly associated with increased risk of adverse events, morbidity, and mortality.
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After caring for patients with Clostridium difficile infection, nearly 25% of health care workers were found to have hand contamination with C. difficile spores.
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This study investigates the role of metabolic dysregulation of the insulin-glucose axis and the risk of obesity-related cancers in the Framingham Heart Study Offspring Cohort over approximately 37 years. The authors found that impaired fasting glucose exposure for a period greater than 10 years increased obesity-related cancer risk.
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A systematic review and meta-analysis of randomized controlled trials of meditation programs demonstrated moderate strength of evidence for mindfulness meditation for improving anxiety, depression, and pain.
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This study reviews a recent example of hepatotoxicity from a dietary supplement and discusses the issues related to retroactively monitoring nutritional supplements for adverse effects.
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The recent publication of the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) and the continuing introduction of new psychoactive drugs create challenges for updated diagnostic and therapeutic choices for primary care patients.