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In this issue: Antiviral drugs and birth defects, bisphosphonates and esophageal cancer, naltrexone plus bupropion for weight loss, 2010-11 influenza vaccine, FDA Actions.
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This study from the University of Amsterdam reports outcome data on 105 consecutive patients resuscitated from primary cardiac arrest and treated in the ICU with a protocol of induced mild hypothermia.
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Management of patients with accidental or intentional poisoning in drug overdose is a common problem for the intensivist. The actual incidence of poisoning in the United States is unknown because of lack of adequate reporting, but a minimum of several million cases occur annually. The vast majority of these cases do not require ICU admission.
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In this secondary analysis of data from a study on the pre-extubation prediction of post-extubation work of breathing in patients recovering from acute respiratory failure, Mehta and colleagues sought to determine whether the size of a patient's endotracheal tube (ETT) affected respiratory rate, tidal volume, and other "weaning parameters" commonly measured during spontaneous breathing and used to predict successful extubation.
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The authors set out to compare arterial and central venous blood gases (ABG and VBG, respectively), to evaluate the utility and accuracy of a predefined algorithm for adjusting VBG pH and pCO2 to approximate that of ABG, and to define clinical scenarios where a VBG may not be a useful substitute for an ABG.
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Of late, there has been a renaissance of interest in identification and management of hypogonadism in older men.
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The FDA has approved the combination of dutasteride (DUT) and tamsulosin (TAM) in a single capsule. Dutasteride is a 5-a reductase inhibitor and tamsulosin is an a-adrenergic antagonist. The combination is marketed by GlaxoSmithKline as Jalyn™.