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Four patients treated with levofloxacin for pneumococcal pneumonia had one or more relapses with levofloxacin-resistant isolates. In 5 of 6 relapses, the infecting strain was identical to the initial levofloxacin-susceptible strain by DNA typing.
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The chimpanzee simian immunodeficiency virus, the virus from which HIV-1 originated, arose as the result of recombination between retroviruses of 2 smaller primates that may serve as a food source for the chimp.
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A study of children with perinatally acquired hepatitis C infection followed for an average of 4.8 years showed persistent HCV infection in 81%, with liver disease that was mild. HCV genotype 3 was associated with a higher rate of loss of HCV RNA and normalization of ALT by 30 months of age.
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The yeast Candida versatilis was isolated from 10 blood cultures from neonates drawn over a period of 10 days.
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Prophylactic administration of immunoglobin failed to demonstrate any benefit among recipients of an allogeneic hematopoietic stem cell transplant from HLA-identical sibling donors.
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Drug discovery activities have yielded agents effective against a novel target in staphylococci.
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The rapid immunochromatographic urine test Binax NOW was found to be a valuable, sensitive, and rapid test for diagnosing pneumococcal pneumonia even after antibiotic therapy had been started.
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Pyrazinamide was the most frequent cause of drug-related adverse events, especially hepatitis, among patients with tuberculosis receiving first-line drugs.