Internal Medicine
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Clostridioides difficile: Risk Factors for Disease
Approximately one-tenth of asymptomatic patients with Clostridioides difficile colonization went on to develop disease. A wide range of antibiotic exposures represent a significant risk.
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Inappropriately Broad Empiric Antibiotics Are Associated with Higher Mortality in Community-Onset Sepsis
A retrospective cohort study found that broad-spectrum antibiotics were unnecessarily prescribed to patients with community-onset sepsis and was associated with worse outcomes and higher mortality.
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Biologic Warfare: A Game-Changer in the Battle Against Malaria?
A non-pathogenic microsporidian organism can infect Anopheles mosquitoes and block the transmission of malaria parasites, without negatively altering the life of the mosquito. This organism potentially could be used for widespread malaria control.
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USPSTF Releases Draft Recommendations for Healthier Diets, More Physical Activity
The panel suggests using behavioral counseling to promote overall better lifestyles, prevent cardiovascular disease.
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Tucatinib Tablets (Tukysa)
Tucatinib should be prescribed in combination with trastuzumab and capecitabine to treat adults with advanced unresectable or metastatic HER2-positive breast cancer.
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Estrogen Replacement: Is Long Duration of Therapy Good for the Brain?
Longer lifetime exposure to endogenous estrogen and menopausal estrogen replacement were associated with better cognitive status in older adult women.
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Heart Failure Confers Increased Risk of Venous Thromboembolic Events
In the Atherosclerosis Risk in Communities (ARIC) cohort, incident heart failure hospitalization with either preserved or reduced ejection fraction was associated with long-term increased risk of venous thromboembolic events.
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For Knee Arthritis: Physical Therapy or the Needle?
In a small, randomized, controlled trial of patients with knee osteoarthritis, those who received physical therapy reported less pain and functional disability at one year than those who received one or more glucocorticoid intra-articular injections. -
Empiric Anti-MRSA Therapy in Pneumonia May Not Always Be a Good Idea
In a retrospective cohort study, empiric anti-methicillin-resistant Staphylococcus aureus treatment was not associated with a reduction in mortality in any subgroup of patients studied and appeared to cause harm in many.
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Early Data on Remdesivir for Severe COVID-19: A Promising Start?
In this group of patients hospitalized with severe COVID-19, the majority of whom required invasive ventilation, 68% showed clinical improvement after treatment with remdesivir on a compassionate-use basis.