Internal Medicine
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Two Possible Mechanisms of Disease in COVID-19
COVID-19 infection may be associated with an increased risk of blood clotting and related thrombotic events, but there are insufficient data to support indiscriminately discontinuing medications that play a critical role in the management of chronic cardiovascular disease.
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Intermittent Fasting for Weight Loss: Hope or Hype?
This article explores the existing evidence for using intermittent fasting as a strategy to promote weight loss. The evidence suggests that intermittent fasting worked as well as continuous energy restriction to achieve weight loss, but was not superior.
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Guillain-Barré, Miller Fisher Syndrome, and Associated Disorders in Patients with COVID-19
As the COVID-19 pandemic spreads around the world, investigators in multiple countries are reporting patients with myriad cranial and peripheral nerve disorders that have some, but not all, features of Guillain-Barré syndrome.
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The Effect of Coronaviruses on the Central Nervous System
Known coronaviruses can enter the central nervous system by different pathophysiologic mechanisms. Neurological presentations linked to the novel SARS-CoV-2 include encephalopathy, encephalitis, cranial neuropathies, Guillain-Barré syndrome and other neuropathies, and ischemic and hemorrhagic strokes.
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Neurologic Manifestations of Hospitalized Patients with COVID-19 in Wuhan, China
Neurological symptoms and impairments have been found in one-third of hospitalized patients with COVID-19 from countries that have reported these observations so far. This is a rapidly evolving consequence of SARS-CoV-2 infection.
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Intermittent Fasting: A Faster Way to a Longer Life?
Intermittent fasting, which once was strictly in the purview of religion and health fads, has undergone a rapid increase in scientific interest. Studies now demonstrate the positive impact that various methods of intermittent fasting can have on overall health.
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Infectious Disease Alert Updates
Complications of Typhoid Fever; Do I Smell a Rat? Or Is the Rat Smelling Me? Cloth Masks — Just for Looks?
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Lefamulin: Formulary Considerations
The Food and Drug Administration (FDA) recently approved lefamulin for the treatment of adults with community-acquired bacterial pneumonia (CABP).
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Antibiotic Therapy to Reduce the Incidence of Ventilator-Associated Pneumonia After Cardiac Arrest
In this prospective, randomized trial, intravenous amoxicillin-clavulanate (dosed three times daily and given for two days) administered to patients admitted with out-of-hospital cardiac arrest due to a shockable rhythm reduced the incidence of early ventilator-associated pneumonia.
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Carbapenem-Resistant Enterobacterales (CRE) in the USA — A Molecular and Clinical Analysis
Patient mortality rates were high among patients from whom carbapenem-resistant Enterobacterales (CRE) were cultured, regardless of whether the organism was causing infection or was a only a colonizer. In addition, mortality was similar regardless of whether a carbapenemase gene was present. Finally, not all “CRE” were truly CRE.