Internal Medicine
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Randomized Diagnostic Trial of First-Line Genome Sequencing in Pediatric White Matter Disorders
The results of this study indicate that first-line genome sequencing in pediatric patients with suspected genetic white matter disease is more diagnostically efficient, defined as higher diagnostic efficacy and shorter time to diagnosis, than current standard of care approaches.
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Plasma Phospho-Tau217 Is a Promising Alzheimer’s Disease Biomarker
Validation and replication of findings in the use of the blood biomarker phospho-tau 217 for the diagnosis of Alzheimer’s disease holds out the possibility for a new era in the early diagnosis and treatment of this debilitating illness.
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Labor, Pain Management, and Acupuncture: A Cochrane Review
This Cochrane review evaluating acupuncture and acupressure for pain management during labor finds acupuncture may lead to reduced use of pharmacological agents for pain control while acupressure may reduce pain intensity. Higher-quality studies are needed.
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Vitamin D and Colon Cancer
A self-report of any vitamin D supplementation is associated with a decrease in colorectal polyps; adjusted odds ratio (aOR) 0.57 (95% confidence interval [CI], 0.33-0.96) in high-latitude conditions. A self report of meeting 600 IU of vitamin D, the recommended daily intake for that region, is associated with a decrease in high-risk adenomatous polyps, with an aOR of 0.78 (95% CI, 0.62-0.99) in high-latitude conditions.
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The Few-Foods Diet and ADHD
This Dutch study describes a six-month follow-up of children with attention deficit hyperactivity disorder (ADHD) introduced to the Few-Foods Diet. Results indicate a significant decrease in ADHD symptoms and medication in children compliant with the diet.
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Assessing and Treating Exacerbations of Chronic Obstructive Pulmonary Disease
People with chronic obstructive pulmonary disease frequently seek care for acute exacerbations, which are associated with significant morbidity and mortality. Therefore, it is crucial for physicians to understand how to assess and treat these patients appropriately.
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Infectious Disease Alert Updates
Things Do Not Always Go Better with Cola; ‘Hygiene Theater’; Geodynamics of COVID-19 in Brazil
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Respiratory Syncytial Virus — Not Just a Disease of Children
Respiratory syncytial virus is a significant cause of morbidity and mortality in the elderly.
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A Novel Rifabutin-Containing Combination Regimen Is Effective for Eradicating H. pylori Infection
A Phase III, randomized, controlled trial found a significantly higher eradication rate for H. pylori with a 14-day regimen of rifabutin, amoxicillin, and omeprazole compared to 14 days of amoxicillin and omeprazole.
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Respiratory Syncytial Virus — Effective Prevention Still Needed
Prevention of respiratory syncytial virus infection is needed but challenging. New studies show some favorable effectiveness on infant outcomes with both vaccination of healthy pregnant women and passive single-dose immunization of prematurely born babies.