Internal Medicine
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What Kind of AV Block?
The ECG in the figure was obtained from a young adult who presented to the emergency department with dizziness, a near syncopal episode, and chest discomfort. Does this ECG suggest AV block is the cause of his symptoms?
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Oliceridine Injection (Olinvyk)
Oliceridine should be prescribed to adults to manage acute pain severe enough to require intravenous opioid analgesic and for whom alternative treatment has not worked.
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Preventing Recurrent Stroke or Death After Ischemic Stroke, TIAs
The combination of ticagrelor and aspirin compared to aspirin alone was superior in reducing the risk of stroke or death within 30 days of an acute ischemic stroke or transient ischemic attack.
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Cilostazol Appears Effective for Long-Term Secondary Stroke Prevention
More trials in Western countries should be initiated to assess the effects of cilostazol treatment on cognitive decline and functional outcomes, as well as on the progression of small vessel disease in the brain. Studies from Asia suggest it is a promising treatment, but it has not been studied sufficiently in clinical trials.
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2020 Updated LTBI Treatment Guidelines
A committee recommended three rifamycin-based regimens and two alternate six- or nine-month isoniazid monotherapy regimens for latent tuberculosis infection treatment. They gave priority to shorter-course regimens with similar efficacy, higher rates of completion, and favorable tolerability compared with the former standard nine-month regimen of isoniazid.
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Diet Modification in Older Women with Fecal Incontinence
This study highlights the need for everyone to inquire and start conversations about fecal incontinence symptoms with patients and empowers clinicians to discuss simple lifestyle modifications that may be of great benefit.
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Guideline: Clinicians Should Use NSAIDs for Acute Musculoskeletal Pain
Orgs call for topical treatment as first-line agent for acute pain from non-low back-related injuries that lasts no more than four weeks.
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Nerve Disorders from Mutations in the BSCL2 Gene
The neuromuscular syndromes caused by BSCL2 gene mutations may mimic several other disorders, including Charcot-Marie-Tooth disease and amyotrophic lateral sclerosis.
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Molecular and Cellular Correlates of Human Nerve Regeneration
Specific and objective measures of improvement after carpal tunnel decompression (i.e., electrodiagnostic testing, somatosensory function, and intraepidermal nerve fiber density) also correlated with upregulation of ADCYAP1/PACAP genes. These genes may be potential therapeutic targets in the future.
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Dermatomyositis Sine Dermatitis Is an Important Clinical Entity
Dermatomyositis is an autoimmune disorder of skeletal muscle associated with a variety of auto-antibodies and specific muscle pathology but it may not have a skin rash. Muscle pathology and antibody determinations are important for accurate diagnosis and treatment.